Progression in autoimmune encephalitis after herpes simplex virus infection

doi:10.3969/j.issn.1006-7795.2021.03.001

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (3): 341-346.doi: 10.3969/j.issn.1006-7795.2021.03.001

• Basic and Clinical Research in Neurology Field • Next Articles

Progression in autoimmune encephalitis after herpes simplex virus infection

Chi Bowen¹, Wang Jiawei^1,2*

1. Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing 100073, China;
2. Central Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Received:2021-03-17 Online:2021-06-21 Published:2021-06-16
Contact: *E-mail:wangjwcq@163.com
Supported by:
National Natural Science Foundation of China General Project (81771313),National Natural Science Foundation of China Youth Fund Project (81301029),Key R&D Program of the Ministry of Science and Technology(2016YFC0904502),Natural Science Foundation of Beijing (19G11041), Beijing Municipal Hospital Administration “Young Miao” Project Special Funding (QML20150206),Beijing Municipal Science and Technology Program “Capital Features” Project (Z171100001017039),Capital Medical Development Key Research Project (2014-1-1101).

Abstract

Abstract: Autoimmune encephalitis caused by herpes simplex virus encephalitis has received increasing attention, the pathogenesis of which may be related to the immune response caused by the release of antigens after the herpes simplex virus infecting neurons. This secondary autoimmune encephalitis has various clinical manifestations, which are easily confused with recurrent herpes simplex virus encephalitis. The delayed treatment may lead to severe neurological deficits and poor prognosis. The detection of autoimmune encephalitis related antibodies in cerebrospinal fluid and serum is helpful for diagnosis. Immunotherapy is effective for autoimmune encephalitis secondary to herpes simplex virus encephalitis. This article reviews the development history, pathogenesis, clinical manifestations, auxiliary examinations, diagnosis, and treatment procedures of autoimmune encephalitis after herpes simplex virus infection.

Key words: herpes simplex virus, autoimmune encephalitis, autoimmune encephalitis related antibodies

CLC Number:

R512.3

Chi Bowen, Wang Jiawei. Progression in autoimmune encephalitis after herpes simplex virus infection[J]. Journal of Capital Medical University, 2021, 42(3): 341-346.

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Progression in autoimmune encephalitis after herpes simplex virus infection

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