Value of 99 mTc-MIBI SPECT planar imaging and tomographic imaging in diagnosis of primary hyperparathyroidism

doi:10.3969/j.issn.1006-7795.2022.06.009

Abstract

Abstract: Objective To assess the diagnostic values of ^{99 m}Tc-MIBI SPECT/CT planar imaging and tomographic imaging in preoperative primary hyperparathyroidism (PHPT). Methods A total of 78 patients in Beijing Chaoyang Hospital from 2019 to 2021 with suspected PHPT who underwent pre-operative^99mTc-MIBI SPECT/CT from January 2019 to January 2021 were retrospectively reviewed.The diagnostic efficacy of early planar imaging, late planar imaging, and tomographic imaging were calculated respectively.The results were compared by χ² test. Results Of all the 78 patients, 20 males (25.64%) and 58 females (74.36%) were included, aged 14-78 (49.36±14.21) years old.Postoperative pathology confirmed 75 patients with PHPT.At patient level, the sensitivity, specificity, and accuracy of early planar imaging were 60.00%, 66.67%, and 60.26%, respectively.The sensitivity, specificity, and accuracy of late planar imaging were 81.33%, 0%, and 78.21%, respectively.The sensitivity, specificity, and accuracy of tomographic imaging were 89.33%, 66.67%, and 88.46%, respectively.The sensitivity and accuracy were significantly higher in late planar imaging and tomographic imaging than that in early planar imaging (χ ²=8.233,P=0.004 and χ ²=17.058,P ＜ 0.001, χ²=5.898,P=0.015 and χ²=16.272,P＜0.001, respectively).At lesion level, the sensitivity, specificity, and accuracy of early planar imaging were 55.42%, 83.33%, and 57.30%, respectively.The sensitivity, specificity, and accuracy of late planar imaging were 73.49%, 16.67%, and 69.66%, respectively.The sensitivity, specificity, and accuracy of tomographic imaging were 90.36%, 66.67%, and 88.76%, respectively.The sensitivity was significantly higher in late planar imaging than that in early planar imaging (χ²=5.916, P=0.015).The sensitivity and accuracy were significantly higher in tomographic imaging than that in early planar imaging and late planar imaging (χ²=25.639, P ＜ 0.001;χ²=22.364, P ＜ 0.001 and χ²=7.975,P=0.005 and χ ²=9.860,P=0.002, respectively). Conclusion The diagnostic values of ^{99 m}Tc-MIBI late imaging in preoperative primary hyperparathyroidism is more significant than that of early imaging.The late tomographic imaging can improve the sensitivity and accuracy.

Key words: primary hyperparathyroidism (PHPT), ^99mTc-MIBI, single-photon emission computed tomography/computed tomography (SPECT / CT)

CLC Number:

Guo Yuehong, Huang Jingwei, Chang Yuting, Yang Minfu. Value of ^{99 m}Tc-MIBI SPECT planar imaging and tomographic imaging in diagnosis of primary hyperparathyroidism[J]. Journal of Capital Medical University, 2022, 43(6): 873-879.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.06.009

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Value of ^{99 m}Tc-MIBI SPECT planar imaging and tomographic imaging in diagnosis of primary hyperparathyroidism

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