Effect of different invasion patterns on the prognosis of patients with T3a renal cell carcinoma

doi:10.3969/j.issn.1006-7795.2023.03.013

Abstract

Abstract: Objective To explore the effect of extrarenal fat invasion (EFI) and renal vein invasion (RVI) on the prognosis of T3a renal cell carcinoma (RCC) patients, in order to provide a better therapy scheme. Methods The basic and clinicopathological information of 8 965 patients with T3a stage was collected from the Surveillance, Epidemiology, and End Results （SEER） database, to analyze the main risk factor of RVI by Logistic regression. The overall survival (OS) and cancer-specific survival (CSS) of patients in the EFI and RVI groups were compared after propensity matching (1∶1). Independent risk factor affecting OS and CSS in T3a RCC patients were analyzed by Cox regression. Results A total of 8 965 T3a patients were enrolled in this study, including 4 803 (53.6%) patients in the EFI group and 4 162 (46.4%) patients in the RVI group. Patients with RVI were more likely to develop bone (6.2% vs 4.9%), lung (15.4% vs 9.0%), and liver (2.5% vs 1.5%) metastases (P<0.05). Age, gender, histological type, tumor size, N stage, and M stage were independent risk factors for RVI (all P<0.05). Compared with the EFI group, patients in the RVI group had a worse 5-year OS (64.0% vs 66.6%, P=0.023) and CSS (72.1% vs 75.1%,P=0.005). RVI was an independent factor affecting OS and CSS in T3a patients (P<0.05). Conclusion Although EFI and RVI belong to T3a stage, the long-term prognosis of patients with RVI is worse than with EFI. For patients with RVI, follow-up examination should be strengthened to improve the prognosis.

Key words: renal cell carcinoma, extrarenal fat invasion, renal vein invasion, prognosis

CLC Number:

R737.11

Wang Runjin, Ye Xiaobo, Zhang Yudong, Zhu Guangyi, Yang Kun, Niu Yinong. Effect of different invasion patterns on the prognosis of patients with T3a renal cell carcinoma[J]. Journal of Capital Medical University, 2023, 44(3): 439-448.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.03.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I3/439

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