Abstract: The establishment and rapid development of molecular biology paved the solid foundation for modern genetics and substantially reshaped related medical research. The human understanding of various diseases in aspect of etiology and genetic profiles has reached in-depth levels given the concept of molecular disease. As a novel discipline gradually established effective research strategy of principle features, including the theme of most consensus and accommodation for basic medical sciences, molecular medicine has made itself become a driving force to advance modern medicine. In this article, we introduced in brief the history of molecular medicine, explored retrospectively the literature contributed by molecular medicine focusing affiliations along medicine, and provided several consideration that might be helpful to the current discipline and curriculum development of basic medicine education, especially for domestic institution in medical universities. In addition, we also discussed in brief the adaptation to the impact or challenge from upcoming trend of artificial intelligence.

Key words: molecular medicine, genetic disease, basic medical science, discipline-based curriculum, ChatGPT