Journal of Capital Medical University ›› 2003, Vol. 24 ›› Issue (3): 225-227.

• 论著·基础研究 • Previous Articles     Next Articles

Effects of Ln3+on Structural Changes of BEL-7402 Cell Proteins

Hong Feng1, Wang Kui1, Li Rongchang1, Huang Peili2   

  1. 1. National Research Laboratory of Natural and Biomimetic Drugs, Peking University;2. Department of Sanitary Chemistry, Capital University of Medical Sciences
  • Received:2002-12-02 Revised:1900-01-01 Online:2003-07-15 Published:2003-07-15

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Abstract: FT-IR revealed that Ln caused the changes of the secondary structure of cellular proteins in Hepes buffer medium. The major changes decreased β-sheet and increased random coil changes of the hydrogen bond and aggregation of proteins obviously.

Key words: rare earth, BEL-7402 cell, FT-IR, protein secondary structure

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