Abstract: Repetitive hyposia method was used to study the adaptation of mice to intermittent hypoxia and the changes of structures and function on neurons cell membrane.The results showed that the specific activity of glutathione peroxidase (GSHpx) decreased (P<0.01) in the mice brain. After many times for intermittent repetitive hypoxia, the activity of GSHpx increased again (P<0.01). The results showed the difference of brain with blood. The adaptation of intermittent hypoxia occurred in the brain. At that time, the contents of gangliosides (Gls), which were enriched in neurons cell membrane, decreased continuously (P<0.01). It is suggested that the structures of neurons cell membrane were damaged by free radical. And this would persist for a long time.

Key words: intermittent repetitive hypoxia, cell membrane, peroxide, glutathione peroxidase