Journal of Capital Medical University ›› 2018, Vol. 39 ›› Issue (5): 759-764.doi: 10.3969/j.issn.1006-7795.2018.05.026

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Effect of nutritional intervention on intestinal barrier in patients with end-stage liver disease

Bi Yanzhen, Chen Yu   

  1. Artificial Liver Treatment & Training Center, Beijing Youan Hospital, Capital Medical University, Beijing Key Laboratory of Liver Failure and Artificial Liver Treatment and Research, Beijing 100069, China
  • Received:2018-08-28 Online:2018-09-21 Published:2018-10-20
  • Supported by:
    This study was supported by National Science and Technology Key Project (2017ZX10203201-005, 2017ZX10202203-006-001, 2017ZX10302201-004-002, 2012ZX10002004-006, 2017ZX10201201), National Key R&D Program of China (2017YFA0103000), "Beijing Muncipal Administration of Hospitals" Ascent Plan (DFL20151601), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201806).

Abstract: The intestine plays an important barrier function, apart from the functions of digestion, absorption and secretion. Most patients with end-stage liver disease have impaired functions of intestinal barrier, leading to bacterial translocation and endotoxemia, which further aggravates liver injury. Malnutrition is also a common complication of patients with end-stage liver disease. The nutritional status of patients directly affects the occurrence, development and prognosis of liver disease. Maintaining the function of the intestinal barrier through nutritional intervention has important clinical significance for the treatment of end-stage liver disease. This review is intended to summarize the latest progresses in this area.

Key words: end-stage liver disease, nutrition, intestinal barrier

CLC Number: