Abstract: Objective  To investigate the prevalence of glucose metabolism abnormalities and related influencing factors in patients with different stages of non-diabetic chronic kidney disease (CKD). Methods  A total of 140 patients with CKD in each stage of the Department of Nephrology, Beijing Bo’ai Hospital, China Rehabilitation Research Center, were selected from April 2020 to April 2022. Among them, 34 were early in CKD (CKD1-3a), 35 were in middle (CKD3b-4), and late stage (CKD5) was 71 cases. The demographic data and clinical biochemical indexes of the patients were recorded, and oral glucose tolerance test (OGTT)  was performed to measure blood glucose, insulin and C-peptide levels at 0, 1, and 2 h, a total of 71 patients completed the OGTT. Results  ① The prevalence of impaired glucose tolerance in the early, middle and late stages of CKD was 42.1%, 41.2%, and 37.1%；The prevalence of dominant diabetes in the early, middle and late stages of CKD was 42.1%, 17.6%, 34.3%;and the abnormal fasting blood glucose in the early, middle, and late stages of CKD was 29.4%, 14.3%, and 14.1%; ② Factors such as gender, blood albumin (ALB), hemoglobin, blood pressure, and blood lipid were corrected, and multivariate Logistic regression analysis revealed that the influencing factors of abnormal glucose metabolism in CKD patients were age, body mass index (BMI), and uric acid, the OR value was 1.057, 1.132, 1.007, with P values was 0.028, 0.035, and 0.012, respectively. That is, the risk of abnormal glucose metabolism increased by about 57% for every 10 years of age, 13.2% for every 1 kg/m2 of BMI, and 70% for every 100 μmol/L of uric acid. Conclusions  ①The prevalence of impaired glucose tolerance in CKD patients is as high as 39.4%, and the proportion of patients with new-onset diabetes is 32.4%, which are significantly higher than the general population (15.5% and 9.7%). ②Patients with CKD have abnormal glucose metabolism in the early stage. ③The influencing factors of abnormal glucose metabolism in CKD patients are age, BMI and uric acid.

Key words: chronic kidney disease, staging of renal function, abnormal glucose metabolism