Abstract: To observe the effect of SGB on endocrine changes at tracheal inubation and incision with general anesthesia and to estimate the effect of cervical sympathetic block on regulating and controlling the stress response during this period of time.Twenty eight ASAⅠ～Ⅱ patients for selective neurosurgery were randomly divided into two groups: Group S contains patients who received left SGB five minutes before induction, while Group N as negetive controll is comprised of those who did not receive SGB.Blood specimens were taken to measure the concentration of plasma corticosteroids, prolactin and insulin before anesthesia induction(t 0), after tracheal indubation (t 1),and at the time of incision(t 2). The patients were induced with fentanyl, pancuroniun, and propofol before tracheal intubation.The results showed that concentrations of COR and PRL decreased while INS increased in group S; Concentrations of COR and PRL increased; while INS decreased in group N. Plama level of COR and PRL in group N significantly increased in comparison with group S(P<0.05, P<0.01). Conclusion: Changes of COR, PRL and INS were relatively smaller after SGB during tracheal intubation and incision with general anesthesia which suggest that SGB before induction effectively suppress the stress response during tracheal intubation and incision in general anesthesia work as stable blood dynamics.

Key words: stellate ganglionic block, tracheal intubation, endocrine changes, stress response