Abstract: To explore the molecular mechanism of hypoxic preconditioning, isolate and analysis the differential genes from the hippocampus of hypoxic preconditioned mice, the technology of mRNA differential display was used and 56 bands of differential genes were recovered. Fourteen of them were purified, cloned, and sequenced. The BLAST results show that nine of them are known genes, while five of them may be unknown genes. The differentially expressed genes will provide a new clue for further study of the molecular mechanisms of hypoxic preconditioning.

Key words: hypoxic preconditioning|mRNA differential display|hippocampus