The 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene in Patients with Coronary Heart Disease

Journal of Capital Medical University ›› 2001, Vol. 22 ›› Issue (2): 119-122.

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The 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene in Patients with Coronary Heart Disease

Fu Yan¹, Wang Xudong¹, Zhai Yanling¹, Fan Zheng², Yang Ling¹, Zhu Yuqing¹, Qi Yahui², Zhao Xiangyin¹

1. Emergency Department, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences;2. Laboratory Centre, Capital University of Medical Sciences

Received:2001-01-03 Revised:1900-01-01 Online:2001-04-15 Published:2001-04-15

Abstract

Abstract: WT5BZ]To investigate the relationship between 4G/5G polymorphism of the plasminogen activator inhibitor-1(PAI-1)gene and coronary heart disease(CHD), genotype at this polymorphism was determined in 123 cases with CHD and 172 controls by polymerase chain reaction using the allele specific primers. Plasma PAI-1 antigen level, PAI activity, cholesterol and triglyceride were measured and body mass index was calculated from all the subjects. The group of CHD had a high number of homozygotes for the deleted allele(4G/4G)of the PAI-1 gene compared with the control(47.2% vs 22.1%, P< 0.05). Mean plasma PAI-1 antigen level and PAI activity varied significantly among the 3 genotypes, being higher in 4G/4G subjects than in 5G/5G subjects 〔(40.87±0.99)μg/L〕 vs 〔(38.14±1.0)μg/L〕, 〔(750±350)U/L〕 vs(650±270)U/L, P<0.05). The PAI-1 4G/5G polymorphism correlated with PAI-1 antigen level to some extent accounts for the development of CHD.

Key words: coronary heart disease, plasminogen activator inhibitor-1, gene polymorphism

CLC Number:

R541.4

Fu Yan;Wang Xudong;Zhai Yanling;Fan Zheng;Yang Ling;Zhu Yuqing;Qi Yahui;Zhao Xiangyin. The 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene in Patients with Coronary Heart Disease[J]. Journal of Capital Medical University, 2001, 22(2): 119-122.

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The 4G/5G Polymorphism of the Plasminogen Activator Inhibitor-1 Gene in Patients with Coronary Heart Disease

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