Analysis of related factors of coronary artery calcification in maintenance hemodialysis patients

doi:10.3969/j.issn.1006-7795.2015.04.023

Abstract

Abstract:

Objective To observe the level of coronary artery calcification in maintain hemodialysis(MHD) patients and explore the relationship between calcium and phosphorus metabolism, fibroblast growth factor 23(FGF23), fetuin-A and coronary artery calcification. Methods Fifty-four MHD patients were enrolled in this study. Phosphate, calcium in their serum were determined. The level of FGF23 and fetuin-A in serum were detected by the method of ELISA. The degree of coronary artery calcification was detected by 64 slice spiral CT and the coronary artery calcium score(CCS) was calculated.The patients were divided into CCS≤400 group and CAC>400 group according to the CCS. Results (1) The mean CCS in 54 MHD patients is 826(P₂₅~P₇₅ is 144~2044). The patients of more than 0 points accounted for 94.44%, more than 100 points accounted for 79.63%, more than 400 points accounted for 59.26%. (2) The FGF23 and age in CCS≤400 group was lower than CCS>400 group. The proportion of coronary disease in group CCS≤400 is lower than that in group CCS>400. The duration of dialysis, calcium, phosphorous, uric acid, albumin, parathyroid hormone, fetuin-A has no significant difference between the two groups. (3) Logistic regression analysis revealed that the level of FGF23 and age was the influencing factor of coronary artery calcification in MHD patients. Conclusion The degree of coronary artery calcification in MHD patients is serious, and the elevation of FGF23 is relevant to the coronary artery calcification.

Key words: fibroblast growth factor 23, fetuin-A, coronary artery calcification, maintenance hemodialysis

CLC Number:

R543.3

Xu Fengbo, Sun Yi, Wang Yinna, Cheng Hao. Analysis of related factors of coronary artery calcification in maintenance hemodialysis patients[J]. Journal of Capital Medical University, 2015, 36(4): 630-633.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.04.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I4/630

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