Polymorphisms in the TIRAP gene has no correlation with pediatric tuberculosis in a Chinese Han children

doi:10.3969/j.issn.1006-7795.2015.04.022

Abstract

Abstract:

Objective Although the Toll-like receptors(TLRs) are responsible for the recognition and response to pathogen ligands, increasing evidence suggests that the family of five cytosolic Toll/IL-1 receptor(TIR) adaptor proteins also play a crucial role in the specificity of the response. To explore the potential role of the TIRAP gene in the susceptibility to TB among members of the Chinese Han Children, we evaluated the association of tag single nucleotide polymorphisms(SNPs) in the TIRAP gene with the risk for TB. Methods We collected 339 TB children and 392 healthy controls in our case-control study and used MassARRAY for genotyping. DNA samples were extracted using the standard salting-out procedure. Results Five tag SNPs were selected. We excluded 2 SNPs(rs563011 and rs8177400), the allelic detection rate of the first one is less than 95% and the AA genotype of the second one is zero. We did not find any statistical significance of distribution analysis of three SNPs of TIRAP genes(rs1786704, rs8177375, rs8177352) in TB group and control group with analysis of alleles, genotypes and haplotypes of SNPs(P>0.05). Conclusion SNPs of TIRAP genes were not associated with TB in Chinese Han children.

Key words: TIRAP, polymorphism, tuberculosis, Chinese Han children, susceptibility

CLC Number:

R725.1

Xiao Jing, Xie Lanpin, Dong Yakun, Wang Xiaoming, Sun Lin, Qi Hui, Shen Adong. Polymorphisms in the TIRAP gene has no correlation with pediatric tuberculosis in a Chinese Han children[J]. Journal of Capital Medical University, 2015, 36(4): 622-629.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.04.022

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I4/622

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