Meta analysis of the association between the polymorphism of XRCC1 Arg280His and lung cancer susceptibility

doi:10.3969/j.issn.1006-7795.2016.06.008

Abstract

Abstract: Objective To evaluate the association between XRCC1 Arg280His and lung cancer susceptibility. Methods To collect the reports of case-control studies on the association between XRCC1 Arg280His and lung cancer susceptibility, we searched CNKI and Pubmed, then evaluated the association of XRCC1 Arg280His and lung cancer susceptibility by Meta analysis. Then we performed subgroup analysis and sensitivity analysis and publication bias test. Results There were 14 studies with 5 711 cases and 6 202 controls enrolled in this Meta-analysis. The pooled OR of His/His+Arg/His genotype compared to Arg/Arg genotype under dominant model was 0.97 without statistically significant association (95%CI:0.78-1.22). Conclusion The XRCC1 Arg280His polymorphism was not statistically significantly associated with the lung cancer susceptibility.

Key words: XRCC1 Arg280His, polymorphism, lung cancer, Meta analysis

CLC Number:

R734.2

Tan Xiaogang, Wang Ruotian, Yao Shuyang, Zhi Xiuyi. Meta analysis of the association between the polymorphism of XRCC1 Arg280His and lung cancer susceptibility[J]. Journal of Capital Medical University, 2016, 37(6): 758-762.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.06.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I6/758

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