Study on the relationship of hypertension in older Han adults with leptin receptor gene rs1137100 and rs1137101 polymorphism

doi:10.3969/j.issn.1006-7795.2017.03.021

Abstract

Abstract: Objective To explore the relationship of hypertension in older Han adults with leptin receptor gene rs1137100 and rs1137101 single nucleotide polymorphism (SNP). Methods The genotypes of rs1137100 and rs1137101 and the allele frequency of 267 older Han adults with hypertension and 255 healthy subjects were determined by the Taqman method. Blood concentrations of lipids, fasting serum glucose, leptin and insulin of those subjects were measured. Association of genotypes of leptin receptor gene SNPs with hypertension was analyzed. Results The hypertension group had higher body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), serum total cholesterol (TC) and the low density lipoprotein cholesterol (LDL-C) levels than that of the healthy group, while the leptin level was significantly lower than that of the healthy group. The GG, AA, GA genotypes distribution and the allele frequency of rs1137100 and rs1137101 were similar between the two groups. In rs1137100, GG and GA genotype had lower TC and LDL-C level than that of AA genotype. In rs1137101, GG and GA genotype had lower TC and LDL-C level than that of AA group; GA+AA group had higher TC and LDL-C level than that of GG group. When comparing with the GG genotypes, the Logistic analysis showed that GA and AA genotypes in rs1137100 had similar risk for hypertension and the OR values were 0.88 (95%CI:0.59-1.28) and 1.15 (95% CI:0.78-1.70), respectively.The GA and AA genotypes in rs1137101 had similar risk for hypertension when comparing with the GG genotypes, and the OR values were 0.90 (95% CI:0.59-1.38) and 1.11(95% CI:0.72-1.71), respectively. Conclusion The rs1137100 and rs1137101 polymorphism are not significantly associated with the prevalence of hypertension in older Han adults.

Key words: leptin receptor, single nucleotide polymorphism, hypertension, older Han adults

CLC Number:

Wu Jinghuan, Zhuo Qin, Tian Yuan, Ma Yanning, Cui Lu, Piao Jianhua, Yang Xiaoguang. Study on the relationship of hypertension in older Han adults with leptin receptor gene rs1137100 and rs1137101 polymorphism[J]. Journal of Capital Medical University, 2017, 38(3): 439-445.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.03.021

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I3/439

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