Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome

doi:10.3969/j.issn.1006-7795.2018.04.006

Abstract

Abstract: Objective This study aims to investigate the relationship between oxidative stress indicators malondialdehyde (MDA), retinol (RET) and the pathogenesis of polycystic ovary syndrome(PCOS). Methods From July to October 2017, 65 cases of PCOS patients in Endocrinology Department of Beijing Gynecology Hospital, Capital Medical University were selected as study group and 24 healthy women who were infertile because of fallopian tube factor or male factor or normal physical examination were selected as control group at the same time. The anthropometric indexes, endocrine indexes, metabolic and oxidative stress indexes of all participants were measured. The characteristics of oxidative stress indicators were compared between PCOS patients and control group. Results Both MDA and superoxide dismutase (SOD) were significantly higher in PCOS group than those in control group (P<0.05), but the RET in PCOS group was significantly lower than that in control group (P<0.05). There was no significant difference in oxidized glutathione (Glut oxyd), total antioxidant activity (TAA), vitamin C (VC), vitamin E (VE) in the two groups (P>0.05). There was a positive correlation between MDA and anti-Müllerian hormone (AMH) (r=0.208, P=0.05) and there was no significant correlation between MDA and testosterone(TT), fasting insulin (FINS), and homeostasis model assessment insulin resistance (HOMA-IR) (P>0.05). There was a negative correlation between RET and AMH (r=-0.232, P<0.05), and there was no significant correlation between RET and TT, FINS, and HOMA-IR (P>0.05). Conclusion The study on multiple oxidative stress markers revealed that the oxidative stress level represented by MDA was increased and the antioxidant level represented by RET was decreased in PCOS patients. Further study of the relationship between oxidative stress and PCOS might be helpful to clarify the pathogenesis of PCOS.

Key words: polycystic ovary syndrome, oxidative stress, malondialdehyde, retinol, pathogenesis

CLC Number:

R711

Wang Husheng, Ruan Xiangyan, Li Yanglu, Cheng Jiaojiao, Gu Muqing, Du Juan, Jin Fengyu, Alfred O. Mueck. Exploration of relationship between malondialdehyde, retinol and pathogenesis of polycystic ovary syndrome[J]. Journal of Capital Medical University, 2018, 39(4): 512-516.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.04.006

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I4/512

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