New progresses in ovarian tissue cryopreservation and transplantation

doi:10.3969/j.issn.1006-7795.2024.04.011

Abstract

Abstract: Ovarian tissue cryopreservation and transplantation not only protect female fertility but also preserve ovarian endocrine function. It is effective in the prevention and treatment of iatrogenic premature ovarian insufficiency, especially in prepubertal girls and women in urgent need of disease treatment. The efficacy and safety of ovarian tissue cryopreservation have proved, and the current clinical gold standard is slow freezing, while vitrification is only for research. Despite the rapid development of this technique in recent years, it still faces problems such as cryoinjury, toxicity of cryoprotectants, assessment of follicular reserve, and safety of cryopreservation and transplantation. This article summarizes the progresses of research on these issues.

Key words: ovarian tissue cryopreservation and transplantation, cryoinjury, follicular reserve, safety

CLC Number:

R711

Du Juan, Ruan Xiangyan. New progresses in ovarian tissue cryopreservation and transplantation[J]. Journal of Capital Medical University, 2024, 45(4): 629-635.

References

［1］ Golezar S, Ramezani Tehrani F, Khazaei S, et al. The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis［J］. Climacteric, 2019, 22(4): 403-411.
［2］ Vogt E C, Real F G, Husebye E S, et al. Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts［J］. Endocr Connect, 2022, 11(5): e220024.
［3］郑荣寿, 陈茹, 韩冰峰, 等. 2022年中国恶性肿瘤流行情况分析［J］. 中华肿瘤杂志, 2024, 46(3): 221-231.
［4］ Siegel R L, Miller K D, Wagle N S, et al. Cancer statistics, 2023［J］. CA Cancer J Clin, 2023, 73(1): 17-48.
［5］ Kim S, Kim S W, Han S J, et al. Molecular mechanism and prevention strategy of chemotherapy- and radiotherapy-induced ovarian damage［J］. Int J Mol Sci, 2021, 22(14): 7484.
［6］ Jadoul P, Donnez J. How does bone marrow transplantation affect ovarian function and fertility?［J］. Curr Opin Obstet Gynecol, 2012, 24(3): 164-171.
［7］ Stuenkel C A, Gompel A. Primary ovarian insufficiency［J］. N Engl J Med, 2023, 388(2): 154-163.
［8］ Ruan X Y. Chinese society of gynecological endocrinology affiliated to the international society of gynecological endocrinology guideline for ovarian tissue cryopreservation and transplantation［J］. Gynecol Endocrinol, 2018, 34(12): 1005-1010.
［9］ Practice Committee of American Society for Reproductive Medicine. Ovarian tissue cryopreservation: a committee opinion［J］. Fertil Steril, 2014, 101(5): 1237-1243.
［10］ Donnez J, Dolmans M M. Fertility preservation in women［J］. Nat Rev Endocrinol, 2013, 9(12): 735-749.
［11］ Oktay K, Harvey B E, Loren A W. Fertility preservation in patients with cancer: ASCO clinical practice guideline update summary［J］. J Oncol Pract, 2018, 14(6): 381-385.
［12］ Lambertini M, Peccatori F A, Demeestere I, et al. Fertility preservation and post-treatment pregnancies in post-pubertal cancer patients: ESMO clinical practice guidelines［J］. Ann Oncol, 2020, 31(12): 1664-1678.
［13］ Kieu V, Stern C, Harris J, et al. Australian fertility preservation guidelines for people with cancer 2022: review and recommendations［J］. Med J Aust, 2022, 217(11): 564-569.
［14］ Donnez J, Dolmans M M, Demylle D, et al. Live birth after orthotopic transplantation of cryopreserved ovarian tissue［J］. Lancet, 2004, 364(9443): 1405-1410.
［15］ Dolmans M M, Donnez J, Cacciottola L. Fertility preservation: the challenge of freezing and transplanting ovarian tissue［J］. Trends Mol Med, 2021, 27(8): 777-791.
［16］ Dolmans M M, Donnez J. Fertility preservation in women for medical and social reasons: oocytes vs ovarian tissue［J］. Best Pract Res Clin Obstet Gynaecol, 2021, 70: 63-80.
［17］ Ruan X, Du J, Korell M, et al. Case report of the first successful cryopreserved ovarian tissue retransplantation in China［J］. Climacteric, 2018, 21(6): 613-616.
［18］ Ruan X, Du J, Lu D, et al. First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency［J］. Climacteric, 2021, 24(6): 624-628.
［19］ Ruan X, Du J, Lu D, et al. First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency［J］. Climacteric, 2022, 25(4): 421-424.
［20］ Ruan X, Cheng J, Korell M, et al. Ovarian tissue cryopreservation and transplantation prevents iatrogenic premature ovarian insufficiency: first 10 cases in China［J］. Climacteric, 2020, 23(6): 574-580.
［21］ Bojic S, Murray A, Bentley B L, et al. Winter is coming: the future of cryopreservation［J］. BMC Biol, 2021, 19(1): 56.
［22］ Lewis J K, Bischof J C, Braslavsky I, et al. The grand challenges of organ banking: proceedings from the first global summit on complex tissue cryopreservation［J］. Cryobiology, 2016, 72(2): 169-182.
［23］ Dou M J, Lu C N, Rao W. Bioinspired materials and technology for advanced cryopreservation［J］. Trends Biotechnol, 2022, 40(1): 93-106.
［24］ Karimi S, Tabatabaei S N, Novin M G, et al. Nanowarming improves survival of vitrified ovarian tissue and follicular development in a sheep model［J］. Heliyon, 2023, 9(8): e18828.
［25］ Hou Y, Lu C N, Dou M J, et al. Soft liquid metal nanoparticles achieve reduced crystal nucleation and ultrarapid rewarming for human bone marrow stromal cell and blood vessel cryopreservation［J］. Acta Biomater, 2020, 102: 403-415.
［26］ Diaz-Dussan D, Peng Y Y, Sengupta J, et al. Trehalose-based polyethers for cryopreservation and three-dimensional cell scaffolds［J］. Biomacromolecules, 2020, 21(3): 1264-1273.
［27］ Shu Z, Heimfeld S, Gao D. Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion［J］. Bone Marrow Transplant, 2014, 49(4): 469-476.
［28］ Pal R, Mamidi M K, Das A K, et al. Diverse effects of dimethyl sulfoxide (DMSO) on the differentiation potential of human embryonic stem cells［J］. Arch Toxicol, 2012, 86(4): 651-661.
［29］ Yang J, Pan C, Zhang J M, et al. Exploring the potential of biocompatible osmoprotectants as highly efficient cryoprotectants［J］. ACS Appl Mater Interfaces, 2017, 9(49): 42516-42524.
［30］ He W, Zhan T J, Han H X, et al. Optimization of deep eutectic solvents enables green and efficient cryopreservation［J］. Langmuir, 2024, 40(1): 624-637.
［31］ Ma J F, Zhang X Y, Cui Z X, et al. Investigation into antifreeze performances of natural amino acids for novel CPA development［J］. J Mater Chem B, 2023, 11(18): 4042-4049.
［32］ Zhang L, Xue X, Yan J, et al. Cryobiological characteristics of l-proline in mammalian oocyte cryopreservation［J］. Chin Med J, 2016, 129(16): 1963-1968.
［33］ Fan Q R, Dou M J, Mao J Q, et al. Strong hydration ability of silk fibroin suppresses formation and recrystallization of ice crystals during cryopreservation［J］. Biomacromolecules, 2022, 23(2): 478-486.
［34］ Rao W, Huang H S, Wang H, et al. Nanoparticle-mediated intracellular delivery enables cryopreservation of human adipose-derived stem cells using trehalose as the sole cryoprotectant［J］. ACS Appl Mater Interfaces, 2015, 7(8): 5017-5028.
［35］ Sugishita Y, Meng L B, Suzuki-Takahashi Y, et al. Quantification of residual cryoprotectants and cytotoxicity in thawed bovine ovarian tissues after slow freezing or vitrification［J］. Hum Reprod, 2022, 37(3): 522-533.
［36］ Taylor M J, Weegman B P, Baicu S C, et al. New approaches to cryopreservation of cells, tissues, and organs［J］. Transfus Med Hemother, 2019, 46(3): 197-215.
［37］ Amorim C A, Donnez J, Dehoux J P, et al. Long-term follow-up of vitrified and autografted baboon (Papio anubis) ovarian tissue［J］. Hum Reprod, 2019, 34(2): 323-334.
［38］ ESHRE Guideline Group on Female Fertility Preservation, Anderson R A, Amant F, et al. ESHRE guideline: female fertility preservation［J］. Hum Reprod Open, 2020, 2020(4): hoaa052.
［39］ Du J, Ruan X Y, Jin F Y, et al. Abnormalities of early folliculogenesis and serum anti-Müllerian hormone in Chinese patients with polycystic ovary syndrome［J］. J Ovarian Res, 2021, 14(1): 36.
［40］ Huang D, Swanson E A, Lin C P, et al. Optical coherence tomography［J］. Science, 1991, 254(5035): 1178-1181.
［41］ Yang H P, Zhang S W, Liu P, et al. Use of high-resolution full-field optical coherence tomography and dynamic cell imaging for rapid intraoperative diagnosis during breast cancer surgery［J］. Cancer, 2020, 126: 3847-3856.
［42］ Watanabe Y, Takakura K, Kurotani R, et al. Optical coherence tomography imaging for analysis of follicular development in ovarian tissue［J］. Appl Opt, 2015, 54(19): 6111-6115.
［43］ Takae S, Tsukada K, Sato Y, et al. Accuracy and safety verification of ovarian reserve assessment technique for ovarian tissue transplantation using optical coherence tomography in mice ovary［J］. Sci Rep, 2017, 7: 43550.
［44］ Takae S, Tsukada K, Maeda I, et al. Preliminary human application of optical coherence tomography for quantification and localization of primordial follicles aimed at effective ovarian tissue transplantation［J］. J Assist Reprod Genet, 2018, 35(4): 627-636.
［45］ Amaral M M, Sun A X, Li Y L, et al. Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography［J］. Biomed Opt Express, 2023, 14(7): 3213-3224.
［46］ Roth Z. Effect of heat stress on reproduction in dairy cows: insights into the cellular and molecular responses of the oocyte［J］. Annu Rev Anim Biosci, 2017, 5: 151-170.
［47］ Liebenthron J, Montag M, Reinsberg J, et al. Overnight ovarian tissue transportation for centralized cryobanking: a feasible option［J］. Reprod Biomed Online, 2019, 38(5): 740-749.
［48］ Cheng J J, Ruan X Y, Zhou Q, et al. Long-time low-temperature transportation of human ovarian tissue before cryopreservation［J］. Reprod Biomed Online, 2021, 43(2): 172-183.
［49］ Isachenko V, Morgenstern B, Todorov P, et al. Long-term (24 h) cooling of ovarian fragments in the presence of permeable cryoprotectants prior to freezing: two unsuccesful IVF-cycles and spontaneous pregnancy with baby born after re-transplantation［J］. Cryobiology, 2020, 93: 115-120.
［50］ Vilela J D M V, Dolmans M M, Amorim C A. Ovarian tissue transportation: a systematic review［J］. Reprod Biomed Online, 2021, 42(2): 351-365.
［51］ Pors S E, Kristensen S G, Nikiforov D, et al. Histidine buffered media maintains pH stabile during cooled transportation of human ovarian tissue［J］. J Ovarian Res, 2021, 14(1): 116.
［52］首都医科大学附属北京妇产医院, 中国人体健康科技促进会生育力保护与保存专业委员会, 阮祥燕. 卵巢组织冻存移植技术规范团体标准［J］. 中国全科医学, 2023, 26(23): 2836-2841.
［53］ Lotz L, Bender-Liebenthron J, Dittrich R, et al. Determinants of transplantation success with cryopreserved ovarian tissue: data from 196 women of the FertiPROTEKT network［J］. Hum Reprod, 2022, 37(12): 2787-2796.
［54］ Canosa S, Maggiulli R, Cimadomo D, et al. Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities and potential new challenges［J］. Reprod Biomed Online, 2023, 47(3): 103252.
［55］ Pomeroy K O, Reed M L, LoManto B, et al. Cryostorage tank failures: temperature and volume loss over time after induced failure by removal of insulative vacuum［J］. J Assist Reprod Genet, 2019, 36(11): 2271-2278.
［56］ Practice Committees of the American Society for Reproductive Medicine, Society for reproductive biologists and technologists, Society for Assisted Reproductive Technology. Cryostorage of reproductive tissues in the in vitro fertilization laboratory: a committee opinion［J］. Fertil Steril, 2020, 114(3): 486-491.
［57］ Dolmans M M, von Wolff M, Poirot C, et al. Transplantation of cryopreserved ovarian tissue in a series of 285 women: a review of five leading European centers［J］. Fertil Steril, 2021, 115(5): 1102-1115.
［58］ Pacheco F, Oktay K. Current success and efficiency of autologous ovarian transplantation: a meta-analysis［J］. Reprod Sci, 2017, 24(8): 1111-1120.
［59］ Rodriguez-Wallberg K A, Milenkovic M, Papaikonomou K, et al. Successful pregnancies after transplantation of ovarian tissue retrieved and cryopreserved at time of childhood acute lymphoblastic leukemia—a case report［J］. Haematologica, 2021, 106(10): 2783-2787.
［60］ Poirot C, Fortin A, Dhédin N, et al. Post-transplant outcome of ovarian tissue cryopreserved after chemotherapy in hematologic malignancies［J］. Haematologica, 2019, 104(8): e360-e363.
［61］ Wikander I, Lundberg F E, Nilsson H, et al. A prospective study on fertility preservation in prepubertal and adolescent girls undergoing hematological stem cell transplantation［J］. Front Oncol, 2021, 11: 692834.
［62］ Kristensen S G, Wakimoto Y, Colmorn L B, et al. Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort［J］. Fertil Steril, 2021, 116(4): 1098-1106.
［63］ Grubliauskaite M, Van der P M E M, Bos A M E, et al. Minimal infiltrative disease identification in cryopreserved ovarian tissue of girls with cancer for future use: a systematic review［J］. Cancers, 2023, 15(17): 4199.
［64］ Zver T, Frontczak S, Poirot C, et al. Minimal residual disease detection by multicolor flow cytometry in cryopreserved ovarian tissue from leukemia patients［J］. J Ovarian Res, 2022, 15(1): 9.

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