丙戊酸钠神经保护作用机制及其应用研究

doi:10.3969/j.issn.1006-7795.2017.03.008

摘要/Abstract

摘要： 丙戊酸钠（sodium valproate）作为一种组蛋白去乙酰酶抑制剂，广泛应用于抗癫痫治疗以及精神分裂、双相障碍等精神疾病的治疗。丙戊酸钠还能对神经元的生长、变异、凋亡产生影响，发挥神经保护作用。丙戊酸钠的作用机制与神经传递和细胞内信号传导通路的调节有关。丙戊酸钠作为神经功能保护药物治疗神经损伤以及认知障碍有待于进一步研究。

关键词: 丙戊酸钠, 神经保护, 信号传导, 组蛋白去乙酰酶抑制剂

Abstract: As an inhibitor of histone deacetylases,sodium valproate is often used in the treatment of neuropsychiatric disorders such as antiepileptic treatment,schizophrenia and bipolar disorder. Sodium valproate can also affect the growth,mutation and apoptosis of neurons and play a neuroprotective effect. The mechanism of neuroprotection of sodium valproate is related to the regulation of neurotransmission and intracellular signaling pathways. Sodium valproate as a neuroprotective drug for the treatment of nerve injury and cognitive impairment remains to be further studied.

Key words: sodium valproate, neuroprotection, signal transduction, histone deacetylase inhibitor

中图分类号:

R971⁺.6

刘全乐, 李天富, 王保国. 丙戊酸钠神经保护作用机制及其应用研究[J]. 首都医科大学学报, 2017, 38(3): 365-371.

Liu Quanle, Li Tianfu, Wang Baoguo. Neuroprotective mechanism of sodium valproate and its application[J]. Journal of Capital Medical University, 2017, 38(3): 365-371.

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