抗环瓜氨酸肽抗体与超声检出的类风湿性关节炎骨侵蚀的相关性研究

doi:10.3969/j.issn.1006-7795.2019.06.004

首都医科大学学报 ›› 2019, Vol. 40 ›› Issue (6): 829-832.doi: 10.3969/j.issn.1006-7795.2019.06.004

抗环瓜氨酸肽抗体与超声检出的类风湿性关节炎骨侵蚀的相关性研究

李文雪¹, 刘芳², 朱家安¹, 刘芳¹, 陈征¹, 李殿城¹

1. 北京大学人民医院超声医学科, 北京 100044;
2. 瑞安市人民医院超声科, 浙江温州 325200

收稿日期:2019-09-09 出版日期:2019-11-21 发布日期:2019-12-18
通讯作者: 朱家安 E-mail:canzhujia@126.com
基金资助:
国家自然科学基金（81571684），北京大学人民医院研究与发展基金（RDY2017-35）。

Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with bone erosion

Li Wenxue¹, Liu Fang², Zhu Jiaan¹, Liu Fang¹, Chen Zheng¹, Li Diancheng¹

1. Department of Ultrasound, Peking University People's Hospital, Beijing 100044, China;
2. Ruian People's Hospital, Wenzhou 325200, Zhejiang Province, China

Received:2019-09-09 Online:2019-11-21 Published:2019-12-18
Supported by:
This study was supported by National Natural Science Foundation of China (81571684), Research and Development Foundation of Peking University People's Hospital (RDY2017-35).

摘要/Abstract

摘要： 目的探讨类风湿性关节炎（rheumatoid arthritis，RA）患者抗环瓜氨酸肽（anti-cyclic citrullinated peptide，ACCP）抗体与超声检出的骨侵蚀的相关性。方法对符合1987年RA分类标准的RA患者的双侧腕关节、第1~5掌指关节及第2~3近节指间关节进行常规灰阶超声和能量多普勒（power Doppler，PD）超声检查，观察关节骨侵蚀、滑膜增厚及PD血流信号情况，分析ACCP抗体阳性和阴性患者的骨侵蚀、滑膜增厚、PD血流信号评分之间的差异，并探讨ACCP、病程与骨侵蚀的关系。结果 RA患者101例，其中女性81例，ACCP抗体阳性患者75例，ACCP抗体阳性组与阴性组的骨侵蚀总评分在两组间差异有统计学意义（P=0.009），而滑膜增厚及PD血流信号总评分在两组间差异无统计学意义。在病程>3年的患者中，ACCP抗体阳性组与阴性组之间的骨侵蚀总评分差异有统计学意义（P=0.01）。结论 ACCP抗体阳性、病程>3年的RA患者有较高的骨侵蚀评分。

关键词: 类风湿性关节炎, 抗环瓜氨酸肽抗体, 超声, 骨侵蚀

Abstract: Objective To explore the relationship between the anti-cyclic citrullinated peptide (ACCP) antibody and bone erosion in patients with rheumatoid arthritis (RA). Methods One hundred and one RA patients were enrolled. Eighty-one of these patients were female, and 75 cases were ACCP positive. Gray scale (GS) and power Doppler (PD) ultrasound was performed to assess bone erosion, synovial hypertrophy, and PD signal. The bilateral wrists, I-V metacarpophalangeal joints, Ⅱ-Ⅲ metacarpophalangeal joints of the hands were detected by GS and PD ultrasound. Appropriate statistical analysis methods were used to analyze the difference of ultrasonographic characteristics in ACCP-positive and ACCP-negative patients, and explore the relationship of the ACCP antibody, disease duration with bone erosion. Results Bone erosion score in ACCP-positive patients was significantly greater than in ACCP-negative patients (P=0.009). No statistically significant difference was observed in synovial hypertrophy and PD signal between ACCP-positive patients and ACCP-negative patients. In RA patients with a disease duration >3 years, however, bone erosion score in ACCP-positive patients was significantly greater than that in ACCP-negative patients (P=0.01). Conclusion ACCP-positive RA patients with a disease duration >3 years had higher bone erosion score.

Key words: rheumatoid arthritis, anti-cyclic citrullinated peptide antibody, ultrasonography, bone erosion

中图分类号:

李文雪, 刘芳, 朱家安, 刘芳, 陈征, 李殿城. 抗环瓜氨酸肽抗体与超声检出的类风湿性关节炎骨侵蚀的相关性研究[J]. 首都医科大学学报, 2019, 40(6): 829-832.

Li Wenxue, Liu Fang, Zhu Jiaan, Liu Fang, Chen Zheng, Li Diancheng. Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with bone erosion[J]. Journal of Capital Medical University, 2019, 40(6): 829-832.

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抗环瓜氨酸肽抗体与超声检出的类风湿性关节炎骨侵蚀的相关性研究

Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with bone erosion

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