专注于胸膜疾病的基础与临床研究——施焕中教授团队

doi:10.3969/j.issn.1006-7795.2020.05.003

摘要/Abstract

摘要： 施焕中教授，现任首都医科大学附属北京朝阳医院呼吸与危重症医学科主任，2019年入选"北京学者"。过去10余年来，施焕中教授带领的团队，在关于胸腔积液基础和临床研究的工作中取得了系列研究成果。

Abstract: Professor Shi Huanzhong has been leader of Division of pleural diseases, Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Chaoyang Hospital, Capital Medical University. His academic achievements were highlighted in this article.

Key words: pleural effusion, lymphocytes, cytokines

中图分类号:

R561.3

施焕中. 专注于胸膜疾病的基础与临床研究——施焕中教授团队[J]. 首都医科大学学报, 2020, 41(5): 736-741.

Shi Huanzhong. Focusing on the basic and clinical research of pleural diseases——Professor Shi Huanzhong's group[J]. Journal of Capital Medical University, 2020, 41(5): 736-741.

参考文献

[1] Chen Y Q, Shi H Z, Qin X J,et al. CD4+CD25+ regulatory T lymphocytes in malignant pleural effusion[J]. Am J Respir Crit Care Med, 2005,172(11):1434-1439.
[2] Qin X J, Shi H Z, Huang Z X,et al. Interleukin-16 in tuberculous and malignant pleural effusions[J]. Eur Respir J,2005, 25(4):605-611.
[3] Qin X J, Shi H Z, Deng J M, et al. CCL22 recruits CD4-positive CD25-positive regulatory T cells into malignant pleural effusion[J]. Clin Cancer Res,2009,15(7):2231-2237.
[4] Ye Z J, Zhou Q, Gu Y Y, et al. Generation and differentiation of IL-17-producing CD4+ T cells in malignant pleural effusion[J]. J Immunol,2010,185(10):6348-6354.
[5] Ye Z J, Zhou Q, Yin W, et al. Differentiation and immune regulation of IL-9-producing CD4⁺ T cells in malignant pleural effusion[J]. Am J Respir Crit Care Med,2012, 186(11):1168-1179.
[6] Ye Z J, Zhou Q, Yin W,et al. Interleukin 22-producing CD4⁺ T cells in malignant pleural effusion[J]. Cancer Lett, 2012, 326(1):23-32.
[7] Lin H, Tong Z H, Xu Q Q, et al. Interplay of Th1 and Th17 cells in murine models of malignant pleural effusion[J]. Am J Respir Crit Care Med,2014, 189(6):697-706.
[8] Wu X Z, Shi X K,Zhai K, et al. Activated naïve B cells promote development of malignant pleural effusion by different regulation of T_H1 and T_H17 response[J]. Am J Physiol Lung Cell Mol Physiol, 2018, 315(3):L443-L455.
[9] Wu X Z, Zhai K, Yi F S, et al. IL-10 promotes malignant pleural effusion in mice by regulating T_H1-and T_H17-cell differentiation and migration[J]. Eur J Immunol,2019, 49(4):653-665.
[10] Zhai K, Shi X Y, Yi F S, et al. IL-10 promotes malignant pleural effusion by regulating T_H1 response via an miR-7116-5p/GPR55/ERK pathway in mice[J]. Eur J Immunol,2020, 10.1002/eji.202048574.
[11] Marazioti A B T, Stathopoulos G T. The lymphatic system in malignant pleural effusion. Drain or immune switch?[J]. Am J Respir Crit Care Med,2014,189(6):626-627.
[12] Xia H, Ye Z J, Zhou Q, et al. IL-27 and IL-27-producing CD4⁺ T cells in human tuberculous pleural effusion[J]. Tuberculosis (Edinb), 2014, 94(6):579-588.
[13] Kimura D, Miyakoda M, Kimura K, et al. Interleukin-27-producing CD4⁺ T cells regulate protective immunity during malaria parasite infection[J]. Immunity, 2016,44(3):672-682.
[14] Ye Z J, Zhou Q, Yuan M L, et al. Differentiation and recruitment of IL-22-producing helper T cells stimulated by pleural mesothelial cells in tuberculous pleurisy[J]. Am J Respir Crit Care Med, 2012, 185(6):660-669.
[15] Ye Z J, Yuan M L, Zhou Q, et al. Differentiation and recruitment of Th9 cells stimulated by pleural mesothelial cells in human Mycobacterium tuberculosis infection[J]. PLoS One, 2012,7(2):e31710.
[16] Tong Z H, Shi H Z. Subpopulations of helper T lymphocytes in tuberculous pleurisy[J]. Tuberculosis (Edinb), 2013, 93(3):279-284.
[17] Yang W B, Liang Q L, Ye Z J, et al. Cell origins and diagnostic accuracy of interleukin 27 in pleural effusions[J]. PLoS One,2012,7(7):e40450.
[18] Wu Y B, Ye Z J, Qin S M, et al. Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy[J]. Chin Med J,2013, 126(17):3215-3221.
[19] Skouras V S, Kalomenidis I. Pleural fluid tests to diagnose tuberculous pleuritis[J]. Curr Opin Pulm Med,2016, 22(4):367-377.
[20] Wang W, Zhou Q, Zhai K, et al. Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion:two prospective studies and one meta-analysis[J]. Thorax, 2018, 73(3):240-247.
[21] Jiang J, Shi H Z, Liang Q L, et al. Diagnostic value of interferon-gamma in tuberculous pleurisy:a metaanalysis[J]. Chest, 2007, 131(4):1133-1141.
[22] Liang Q L, Shi H Z, Wang K, et al. Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy:a meta-analysis[J]. Respir Med, 2008, 102(5):744-754.
[23] Zhou Q, Chen Y Q, Qin S M, et al. Diagnostic accuracy of T-cell interferon-gamma release assays in tuberculous pleurisy:a meta-analysis[J]. Respirology,2011, 16(3):473-480.
[24] Liang Q L, Shi H Z, Qin X J, et al. Diagnostic accuracy of tumour markers for malignant pleural effusion:a meta-analysis[J]. Thorax, 2008, 63(1):35-41.
[25] Luo L, Shi H Z, Liang Q L, et al. Diagnostic value of soluble mesothelin-related peptides for malignant mesothelioma:a meta-analysis[J]. Respir Med,2010, 104(1):149-156.
[26] Shi H Z, Liang Q L, Jiang J, et al. Diagnostic value of carcinoembryonic antigen in malignant pleural effusion:a meta-analysis[J]. Respirology, 2008, 13(4):518-527.
[27] Cui A, Jin X G, Zhai K, et al. Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma:updated meta-analysis[J]. BMJ Open, 2014, 4(2):e004145.
[28] Gu Y, Zhai K, Shi H Z. Clinical value of tumor markers for determining cause of pleural effusion[J]. Chin Med J (Engl), 2016,129(3):253-258.
[29] Zhai K, Wang W, Wang Y, et al. Diagnostic accuracy of tumor markers for malignant pleural effusion:a derivation and validation study[J]. J Thorac Dis,2017, 9(12):5220-5229.
[30] Yang Y, Liu Y L, Shi H Z. Diagnostic accuracy of combinations of tumor markers for malignant pleural effusion:An updated meta-analysis[J]. Respiration,2017, 94(1):62-69.
[31] Yang M F, Tong Z H, Wang Z, et al. Development and validation of the PET-CT score for diagnosis of malignant pleural effusion[J]. Eur J Nucl Med Mol Imaging, 2019,46(7):1457-1467.
[32] Wang X J, Yang Y, Wang Z, et al. Efficacy and safety of diagnostic thoracoscopy in undiagnosed pleural effusions[J]. Respiration, 2015, 90(3):251-255.
[33] Wang Z, Xu L L, Wu Y B, et al. Diagnostic value and safety of medical thoracoscopy in tuberculous pleural effusion[J]. Respir Med,2015, 109(9):1188-1192.
[34] Yang Y, Wu Y B, Wang Z, et al. Long-term outcome of patients with nonspecific pleurisy at medical thoracoscopy[J]. Respir Med,2017, 124:1-5.