关键词: 2型糖尿病, 肾小球滤过率, 尿白蛋白排泄率, 糖尿病肾病

Abstract: Objective: The purpose was to study the relationship between urinary albumin excretion rate (UAER) and glomerular filtration rate(GFR) in type 2 diabetic patients. 154 diabetic patients in hospital were divided on the basis of UAER into a normal albuminuria group (<20μg/min), a microal-buminuria group (20～200 μg/min), and a overt albuminuria group ( >200μg/min). GFRwas measured by the ^99mTc-DTPA single injection method. Glycosylated hemoglobin, plasma creatinine and systolic blood pressures were also analyzed. Result: GFR in the overt albuminuria group fell consistently (P<0.01), while its UAERrose significantly(P<0.01 ). Similarly, compared with the normal albuminuria group respectively, systolic blood pressures and glycosylated hemoglobin were significantly higher in the microalbuminuria group and overt albuminuria group(P<0.01). GFR was independently negatively correlated to UAER, ages, plasma creatinine, systolic blood pressure and glycosylated hemoglobin. Multiple regression analysis disclosed that UAER, ages, plasma creatinine, glycosylated hemoglobin and systolic blood pressure were the primary factors which caused GFR to come down. Conclusion: Diabetic patients'renal function should be exactly judged by measuring both GFRand UAER. Intensive control of glycosylated hemoglobin and systolic blood pressure important for postponing the decline in GFRand the development of microalbuminuria.

Key words: type 2 diabetes mellitus, glomerular filtration rate, urinary albumin excretion rate, diabetic nephropathy