关键词: 颈动脉, 动脉粥样硬化斑块, 相关因素, 独立危险因素, 心脑血管疾病

Abstract: Objective To investigate the risk factors related to the formation of the carotid atherosclerotic plaque so as to prevent and treat the cardiovascular or cerebrovascular diseases evidentially as early as possible.Methods A total of 192 inpatients admitted to the Medicine Department from July 2006 to July 2007 were included.They were all examined with the carotid colour Doppler flow imaging,and were grouped as plaque group(n=109) and non plaque group(n=83) according to the results of duplex color Doppler flow imaging.Patients of the two groups were compared statistically in the level of some possible risk factors including age,sex,drinking,smoking,hypertension,glycometabolism abnormality,blood glucose(BG),blood cholesterin(CHOL)and triglyceride(TC),high density lipoprotein(HDL)and low density lipoprotein(LDL).Logistic regression model was applied in the screening of risk factors.Results The mean age,mean total cholesterol,mean triglyceride,incidences of hypertension and abnormal glycometabolism were significantly higher in patients with carotid plaques than in patients without by single-factor analysis.No significant difference of sex,drinking,smoking,the mean value of low-density lipoprotein,high-density lipoprotein and glucose was found between two groups.Logistic multi-factor regression analysis showed that age(OR=1.10,P=0.002),hypertension(OR=2.81,P=0.031) and abnormal glycometabolism(OR=2.74,P=0.028) were involved in the regression equation statistically.Conclusion The formation of the carotid atherosclerotic plaque is interactional result of multiplicate factor.High total cholesterol and high triglyceride are the related risk factors of carotid plaque.Age,hypertension and abnormal glycometabolism are the possible independent risk factors for carotid plaque.

Key words: carotid, atherosclerotic plaque, liability, independent risk factors, cardiovascular or cerebrovascular diseases