关键词: 血清铁蛋白, 氧化型低密度脂蛋白, 总胆红素, 冠状动脉粥样硬化, 冠状动脉粥样硬化性心脏病

Abstract: Objective To investigate the relationship of serum ferritin(SF),oxidized low density lipoprotein(Ox-LDL),total bilirubin(TBIL),the ratio of serum ferritin and total bilirubin(SF/TBIL) and Gensini scores in patients with coronary heart disease(CHD) and to appraise the diagnosis of CHDby measuring SF/TBIL.Methods Gensini scores,SF,TBIL,Ox-LDL,SF/TBIL,total cholesterol(TC),triglycerides(TG),high density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) were calculated and measured in 70 CHD and 62 NCHD diagnosed by coronary arterography.Results CHDgroup showed significant high levels of SF,Ox-LDL,SF/TBIL,LDL-C(P<0.01),and low levels of TBILand HDL-C(P<0.05) when compared with NCHDgroup.In CHDgroup,Ox-LDLand Gensini scores were positively correlated with SF(r=0.423,P<0.01;r=0.534,P<0.01) and SF/TBIL(r=0.481,P<0.01;r=0.604,P<0.01) while negatively correlated with TBIL(r=-0.346,P<0.01;r=-0.484,P<0.01).To analyze SF/TBILby ROC,the area under the ROCcurve was 0.895(P<0.01) and the sensitivity and specificity of diagnosing CHDwere 85.7% and 82.3% when SF/TBILwas 16.5559.TC,HDL-C,TBIL and SF/TBIL entered Logistic equation.Conclusion SF/TBIL,a risk factor of CHD,reflects the influential factors of coronary atherosclerosis more comprehensively and objectively than SFor TBIL.To CHD,SF/TBILhas certain diagnostic value.Both lower bilirubin and higher serum ferritin promote coronary heart disease.

Key words: serum ferritin, oxidized low density lipoprotein, total bilirubin, coronary atherosclerosis, coronary heart disease