脑静脉窦血栓形成动物模型研究进展

doi:10.3969/j.issn.1006-7795.2023.05.002

摘要/Abstract

摘要： 脑静脉窦血栓形成（cerebral venous sinus thrombosis, CVST）是卒中的特殊亚型，占所有脑卒中的0.5%~1%，好发于青壮年和女性。其病理机制复杂，诊断困难，漏诊及误诊率高，重症病死率高达30%，是神经科的疑难病。除血栓形成外，还伴有不同的CVST相关实质损伤，包括水肿、缺血性卒中和脑内出血。为了进一步探索CVST的病理演变规律及分子病理特征，需要建立适宜的CVST动物模型，以研究CVST血栓形成、脑组织损伤等分子病理机制以及相关防治方案。本篇综述主要概述了现有的CVST实验动物模型，重点分析了每一种模型的优势、局限性和当前相关研究的应用，以期为CVST的基础研究提供借鉴。

关键词: 脑血管病, 脑卒中, 脑静脉窦血栓形成, 动物模型, 静脉性卒中

Abstract: Cerebral venous sinus thrombosis (CVST) is a special subtype for 0.5%-1% of all strokes，and it tends to occur in young adults and women. It is a difficult disease in neurology because of its complex pathology. The clinical diagnosis is difficult, with high rate of missed diagnosis and misdiagnosis, and severe mortality rate up to 30%. Beyond thrombosis, different CVST-related parenchymal injuries may occur and include edema, ischemic strokes, and intra-cerebral hemorrhage. There are many uncontrollable factors involved during CVST development. In order to further explore the pathological evolution and molecular pathological characteristics of CVST, it is necessary to establish a suitable animal model of CVST to study the molecular pathological mechanisms of CVST thrombosis, brain tissue damage and related prevention and treatment programs. Importantly， animal models are useful to study new therapeutic approaches. In this review, we provide a mainly overview of CVST experimental animal models, focusing on their strengths, limits, and applications for relevant studies.

Key words: cerebrovascular disease, stroke, cerebral venous sinus thrombosis, animal models, venous stroke

中图分类号:

R543

马薇, 周一帆, 姜慧敏, 卫慧敏, 周陈, 吉训明. 脑静脉窦血栓形成动物模型研究进展[J]. 首都医科大学学报, 2023, 44(5): 704-714.

Ma Wei, Zhou Yifan, Jiang Huimin, Wei Huimin, Zhou Chen, Ji Xunming. Research progresses in cerebral venous sinus thrombosis animal models[J]. Journal of Capital Medical University, 2023, 44(5): 704-714.

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