针刺治疗对阴虚火旺型抑郁症的血清BDNF影响

doi:10.3969/j.issn.1006-7795.2016.02.014

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (2): 176-180.doi: 10.3969/j.issn.1006-7795.2016.02.014

针刺治疗对阴虚火旺型抑郁症的血清BDNF影响

王群松, 季向东, 朱文娴, 于海燕

无锡市精神卫生中心中西医结合精神科, 江苏无锡 214151

收稿日期:2016-01-20 出版日期:2016-04-21 发布日期:2016-04-14
通讯作者: 于海燕 E-mail:yhywx911@163.com
基金资助:
"十二五"国家科技支撑计划项目(2011BAI08B01),国家自然科学基金(81302516, 81373099),北京市自然科学基金重点项目(7131002),教育部人文社科基金(13YJCZH090)

Effect of acupuncture on the serum brain-derived neurotrophic factor level in depressive patients with hyperactivity of “Fire” due to “Yin” deficiency

Wang Qunsong, Ji Xiangdong, Zhu Wenxian, Yu Haiyan

Department of Integrated Traditional Chinese Medicine and Western Medicine Psychiatry, Wuxi Mental Health Center, Wuxi 214151, Jiangsu Province, China

Received:2016-01-20 Online:2016-04-21 Published:2016-04-14
Supported by:
This study was supported by National Twelfth Five-year Science and Technology Support Program (2011BAI08B01), National Natural Science Foundation of China (81302516, 81373099), Key Project of Beijing Natural Science Foundation (7131002), Humanities and Social Sciences Fund of the Ministry of Education, China (13YJCZH090).

摘要/Abstract

摘要： 目的评价针刺对阴虚火旺型抑郁症患者的疗效及血清脑源性神经营养因子(brain derived neurotrophic factor,BDNF)浓度影响。方法将64例阴虚火旺型抑郁症患者采用数字表法随机分为两组,试验组(n=32)接受针刺治疗,对照组(n=32)接受米氮平治疗,疗程为8周,分别于治疗前后抽取外周静脉血检测血清BDNF浓度,并在入组时、治疗4周末及8周末评定汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)-24来评估疗效,比较两组治疗前后血清BDNF浓度的变化及HAMD评分差异,并在8周末采用Asberg抗抑郁药不良反应量表(Side Effects Rating Scale,SERS)评估两组不良反应情况。结果 1治疗前两组HAMD评分差异无统计学意义(P>0.05),重复测量方差分析发现,评定时间主效应显著(F=381.87, P=0.000),事后检验(LSD法)发现,两组治疗4周末、8周末的HAMD-24评分均较治疗前显著降低,且治疗8周末的评分显著低于治疗4周末(P均<0.05),但在每个时间点上两组间差异无统计学意义(P>0.05);评定时间组别的交互作用不显著(F=0.063, P=0.939),组间效应不显著(F=0.008, P=0.931);根据治疗8周末的HAMD减分率计算试验组有效率为71.88%,对照组有效率为75%,组间差异无统计学意义(P>0.05);2治疗前两组血清BDNF浓度差异无统计学意义(P>0.05),经治疗后两组血清BDNF浓度均显著升高(P<0.05),组间差异无统计学意义(P>0.05);3治疗8周末试验组SERS评分显著低于对照组(P<0.05)。结论针刺可显著提高阴虚火旺型抑郁症患者的血清BDNF浓度,其抗抑郁作用与米氮平相当,且无明显不良反应。

关键词: 抑郁症, 阴虚火旺型, 针刺, 脑源性神经营养因子

Abstract: Objective To evaluate the effect of acupuncture on the serum brain-derived neurotrophic factor (BDNF) level and the clinical efficacy in patients with depressive disorder of hyperactivity of "fire" due to "yin" deficiency type. Methods Sixty-four depressive patients with hyperactivity of fire due to yin deficiency were randomly allocated into two groups. The trial group (n=32) were treated with acupuncture and the control group (n=32) were treated with mirtazapine for 8 weeks, respectively. The serum BDNF concentration was tested for every subject before and after the treatment; meanwhile, the HAMD-24 was assessed at the baseline, 4-week and 8-week after treatment. The between-group differences were analyzed, and the side effects were evaluated using the Asberg Rating Scale for Side Effects (SERS). Results The total HAMD scores were comparable between the two groups before treatment. Repeated measures analysis of variance revealed a significant main effect of time (F=381.87, P=0.000), and the post-hoc analysis (least-significant difference test) indicated that the HAMD scores after 4-week treatment were lower than those of the baseline, and the HAMD scores further decreased after 8-week treatment (All P<0.05), in both groups; whereas there was no significant difference between the two groups at any time point (All P>0.05). Neither the interactive effect of time × group nor the between-group effect was significant (F=0.063, P=0.939, and F=0.008, P=0.931, respectively). The reduction rate of HAMD at 8-weekend of the trial group was comparable to that of the control group (71.88% vs 75.00%, P>0.05). The serum BDNF levels of both groups increased significantly (both P<0.05) after treatment but there was no significant between-group difference either at the baseline or at the follow-up (both P>0.05). After 8-week treatment, the SERS score of the trial group was significantly lower than that of the control group (P<0.05). Conclusion Acupuncture could significantly improve the serum BDNF levels in depressive patients with hyperactivity of "Fire" due to "Yin" deficiency, and it has comparable anti-depressive effects to mirtazapine without causing obvious side effects.

Key words: depressive disorder, hyperactivity of Fire due to Yin deficiency, acupuncture, brain-derived neurotrophic factor

中图分类号:

R749.4

王群松, 季向东, 朱文娴, 于海燕. 针刺治疗对阴虚火旺型抑郁症的血清BDNF影响[J]. 首都医科大学学报, 2016, 37(2): 176-180.

Wang Qunsong, Ji Xiangdong, Zhu Wenxian, Yu Haiyan. Effect of acupuncture on the serum brain-derived neurotrophic factor level in depressive patients with hyperactivity of “Fire” due to “Yin” deficiency[J]. Journal of Capital Medical University, 2016, 37(2): 176-180.

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针刺治疗对阴虚火旺型抑郁症的血清BDNF影响

Effect of acupuncture on the serum brain-derived neurotrophic factor level in depressive patients with hyperactivity of “Fire” due to “Yin” deficiency

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