膀胱过度活动症患者脑1H-MRS成像特点及临床相关分析

doi:10.3969/j.issn.1006-7795.2017.06.014

首都医科大学学报 ›› 2017, Vol. 38 ›› Issue (6): 846-850.doi: 10.3969/j.issn.1006-7795.2017.06.014

• 神经系统疾病的基础和临床研究 • 上一篇下一篇

膀胱过度活动症患者脑¹H-MRS成像特点及临床相关分析

周洋¹, 王双坤¹, 左龙¹, 王飚², 顾华¹

1. 首都医科大学附属北京朝阳医院放射科, 北京 100020;
2. 首都医科大学附属北京朝阳医院泌尿外科, 北京 100020

收稿日期:2017-10-01 出版日期:2017-11-21 发布日期:2017-12-16
通讯作者: 王双坤 E-mail:shuangkunwang@126.com
基金资助:
国家自然科学基金（81541129）。

Brain ¹H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms

Zhou Yang¹, Wang Shuangkun¹, Zuo Long¹, Wang Biao², Gu Hua¹

1. Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
2. Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Received:2017-10-01 Online:2017-11-21 Published:2017-12-16
Supported by:
The study was supported by National Natural Science Foundation of China (81541129).

摘要/Abstract

摘要： 目的利用氢质子磁共振波谱（proton magnetic resonance spectroscopy，¹H-MRS）成像探讨膀胱过度活动症（overactive bladder，OAB）患者特定脑区的代谢变化。方法选择临床确诊的膀胱过度活动症患者23例，健康志愿者23例，记录所有受试者的抑郁自评量表（Self-rating Depression Scale，SDS）评分及患者的膀胱过度活动症患者自我评价量表（Overactive Bladder Symptom Score，OABSS）评分。所有受试者接受颅脑多体素¹H-MRS扫描，并利用专用的后处理软件计算双侧额叶前部、中部、后部及双侧扣带回前部、后部的N-乙酰基天门冬氨酸（N-acetyl aspartate，NAA）/磷酸肌酸（creatine，Cr）、胆碱化合物（choline，Cho）/Cr比值，进行组间比较。并且，利用Pearson相关系数对NAA/Cr、Cho/Cr比值与SDS、OABSS评分进行相关分析。结果 OAB患者双侧额叶前部、右侧额叶中部、双侧前扣带回、左侧后扣带回的NAA/Cr值较对照组降低，其余指标差异无统计学意义（P>0.05）。OAB组右侧额叶中部NAA/Cr比值与SDS评分呈负相关（r=-0.361，P<0.05）。结论 ¹H-MRS能够反映OAB患者的脑部代谢变化，为进一步的治疗提供理论依据。

关键词: 膀胱过度活动症, 磁共振波谱成像, 脑

Abstract: Objective To measure the metabolic changes of the brain using the proton magnetic resonance spectroscopy (¹H-MRS) in the patients with overactive bladder (OAB).Methods We recruited 23 patients with OAB and 23 healthy controls respectively. All participants were evaluated with Self-Rating Depression Scale (SDS) and 23 patients were evaluated with Overactive Bladder Symptom Score (OABSS). Multi-voxel ¹H-MRS was performed with a volume of interest located in the centrum semiovale which contains both frontal lobe and cingulate gyrus. Two main ratios of N-acetyl aspartate (NAA)/creatine (Cr) and choline (Cho)/Cr were obtained. The ratios in both frontal lobe and cingulategyrus between the two groups were compared. And the correlation between NAA/Cr, Cho/Cr and SDS, OABSS scores were analyzed. Results We found significantly lower levels of NAA/Cr ratios in both anterior frontal cortex, right medial frontal cortex, both anterior cingulate cortex and left posterior cingulate cortex in patients with OAB than in healthy controls (P<0.05). NAA/Cr in right medial frontal cortex was negatively correlated with SDS scores (r=-0.361,P<0.05).Conclusion The primary finding of the study is significant reduction in the ratios of NAA/Cr in both anterior frontal cortex, right medial frontal cortex, both anterior cingulate cortex and left posterior cingulate cortex in OAB patients, which indicates a marker of neuronal loss or dysfunction in patients with OAB.

Key words: overactive bladder, magnetic resonance spectroscopy, brain

中图分类号:

R445.2

周洋, 王双坤, 左龙, 王飚, 顾华. 膀胱过度活动症患者脑¹H-MRS成像特点及临床相关分析[J]. 首都医科大学学报, 2017, 38(6): 846-850.

Zhou Yang, Wang Shuangkun, Zuo Long, Wang Biao, Gu Hua. Brain ¹H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms[J]. Journal of Capital Medical University, 2017, 38(6): 846-850.

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膀胱过度活动症患者脑¹H-MRS成像特点及临床相关分析

Brain ¹H-MRS imaging characteristics in patients with overactive bladder and its correlation with clinical symptoms

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