冠状动脉早期粥样硬化症患者冠状动脉钙化的影响因素分析

doi:10.3969/j.issn.1006-7795.2020.06.018

摘要/Abstract

摘要： 目的探讨冠状动脉早期粥样硬化症患者冠状动脉钙化与心血管疾病危险因素的相关性。方法选取2013年6月至2015年6月首都医科大学宣武医院心脏内科收治的疑诊冠状动脉粥样硬化性心脏病(以下简称冠心病)、行冠状动脉电子计算机断层扫描血管造影(coronary computed tomographic angiography, CCTA)检查、并经冠状动脉造影检查证实为冠状动脉早期粥样硬化症(冠状动脉狭窄＜30%)的127例患者为研究对象,其中男性69例,女性58例,年龄31～85岁,平均年龄(59±11)岁。专业培训人员对研究对象采用标准化问卷进行调查及临床资料收集,并行踝臂指数(ankle brachial index,ABI)和血流介导内皮依赖性血管舒张功能(flow mediated dilatation, FMD)检测,计算冠状动脉钙化积分(coronary artery calcification score, CACS),CACS＞0认为存在冠状动脉钙化,为钙化组,CACS=0为非钙化组。结果单因素分析显示,钙化组患者年龄、合并高血压病史的比例高于非钙化组(P=0.001, P=0.003),ABI低于非钙化组(P=0.006)。以冠状动脉是否钙化为因变量,进行多因素Logistic回归分析显示,年龄和ABI是影响冠状动脉钙化的独立因素。结论在冠状动脉早期粥样硬化人群中,年龄和ABI与冠状动脉钙化显著相关。

关键词: 冠状动脉钙化, 冠状动脉钙化积分, 踝臂指数, 高血压, 冠状动脉粥样硬化

Abstract: Objective To analyze the influencing factors of coronary artery calcification (CAC) in patients with early coronary atherosclerosis. Methods A total of 127 consecutive patients (69 males and 58 females, and mean age 59 years) with suspected coronary artery disease confirmed early coronary atherosclerosis (coronary stenosis＜30%) with coronary computed tomographic angiography and coronary angiography were enrolled between June 2013 and June 2015. Clinical data were recorded, and ankle brachial index (ABI) and flow mediated dilatation were measured. The patients were divided into CAC group (CAC score＞0) and non-CAC group (CAC score=0). Results In the univariant analyses, compared with the non-CAC group, CAC group patients were associated with older age and a higher proportion of hypertension(both P<0.05). ABI in non-CAC group was significant higher than that in CAC group (P<0.05). Logistic regression analysis revealed that age and ABI significantly and independently correlated with the occurrence of CAC. Conclusion Age and ABI were strongly associated with the CAC in early coronary atherosclerosis patients.

Key words: coronary artery calcification, coronary artery calcification score, ankle brachial index, hypertension, coronary atherosclerosis

中图分类号:

R541.4

谭静, 李静, 张迎花, 左雪冰. 冠状动脉早期粥样硬化症患者冠状动脉钙化的影响因素分析[J]. 首都医科大学学报, 2020, 41(6): 978-981.

Tan Jing, Li Jing, Zhang Yinghua, Zuo Xuebing. Influencing factors of coronary artery calcification in patients with early coronary atherosclerosis[J]. Journal of Capital Medical University, 2020, 41(6): 978-981.

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