α-Synuclein Promotes Neurite Outgrowth of Primarily Cultured Rat Brain Neurons

doi:10.3969/j.issn.1006-7795.2009.05.008

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (5): 607-610.doi: 10.3969/j.issn.1006-7795.2009.05.008

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α-Synuclein Promotes Neurite Outgrowth of Primarily Cultured Rat Brain Neurons

LIU Guang-wei¹, WANG Peng², LI Yao-hua¹, LI Xin¹, HE Xin², YU Shun¹

1. Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education;2. Department of Human Anatomy, School of Medicine, Beihua University

Received:2009-07-16 Revised:1900-01-01 Online:2009-10-21 Published:2009-10-21

Abstract

Abstract: Objective To investigate the effect of α-Synuclein(α-Syn) on the neurite outgrowth of brain neurons. Methods Neurons isolated from the neocortex of newborn rats were cultured and α-Syn was added into the culture medium to observe the effect of the protein on the neurite outgrowth of the neurons. In addition, the effect of different concentrations of α-Syn on the neurite outgrowth was studied. Results The mean neurite length of the neurons treated with α-Syn was significantly longer than that of control neurons at 1 h, 2 h and 4 h after adding α-Syn. The effect of α-Syn on neurite outgrowth was enhanced with the increase of α-Syn concentration and was reversed by anti-α-Syn monoclonal antibody. Conclusion α-Syn can promote neurite outgrowth of primary rat brain neurons in a dose-dependent manner.

Key words: α-synuclein, neuron, neurite, rat

CLC Number:

Q189

LIU Guang-wei;WANG Peng;LI Yao-hua;LI Xin;HE Xin;YU Shun. α-Synuclein Promotes Neurite Outgrowth of Primarily Cultured Rat Brain Neurons[J]. Journal of Capital Medical University, 2009, 30(5): 607-610.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2009.05.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2009/V30/I5/607

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α-Synuclein Promotes Neurite Outgrowth of Primarily Cultured Rat Brain Neurons

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