Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C

doi:10.3969/j.issn.1006-7795.2012.03.011

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (3): 334-337.doi: 10.3969/j.issn.1006-7795.2012.03.011

• 丙型肝炎宿主基因型与检测 • Previous Articles Next Articles

Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C

TONG Xiao-fei, YOU Hong

Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2012-02-14 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

Abstract

Abstract: The current standard of care for chronic infection with hepatitis C virus is pegylated interferon-alfa(PEG-IFN) and ribavirin (RBV).Genetic variation in interleukin 28-B ( IL-28B ) play an important role in treatment response of chronic hepatitis C. It may be a strong predictor for the therapy of interferon. This paper discusses the significance of IL-28B in the therapy of chronic hepatitis C through the relationship between IL-28B and treatment response with its possible mechanism.

Key words: hepatitis C, genome-wide association study, interleukin 28-B, interferon-λ, interferon-α

CLC Number:

R 512.6⁺3

TONG Xiao-fei;YOU Hong. Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C[J]. Journal of Capital Medical University, 2012, 33(3): 334-337.

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Genetic polymorphisms of interleukin 28-B play an important role in response to treatment of chronic hepatitis C

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