The 2016 Lasker Awards

doi:10.3969/j.issn.1006-7795.2016.05.028

Abstract

Abstract: In September 13, 2016, the list of winners of the year's Lasker Awards were released. The 2016 Albert Lasker Basic Medical Research Award honors William G. Kaelin, Jr., Peter J. Ratcliffe and Gregg L. Semenza, for their discovery of the pathway by which cells from human and most animals sense and adapt to changes in oxygen availability, a process that is essential for survival. The 2016 Albert Lasker Clinical Medical Research Award honors Ralf F. W. Bartenschlager, Charles M. Rice and Michael J. Sofiafor, who developed a system to study the replication of the virus that causes hepatitis C and used this system to revolutionize the treatment of this chronic, often lethal disease. The 2016 Lasker Award for Special Achievement in Medical Science honors Bruce M. Alberts for fundamental discoveries in DNA replication and protein biochemistry; for visionary leadership in directing national and international scientific organizations to better people's lives; and for passionate dedication to improving education in science and mathematics.

Key words: Lasker Awards, HIF-1, hepatitis C virus (HCV), DNA replication

Li Yuzheng, Zhang Ting, Wang Xiaomin. The 2016 Lasker Awards[J]. Journal of Capital Medical University, 2016, 37(5): 703-710.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.05.028

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I5/703

References

[1] 朱安远,郭华珍. 诺贝尔奖的风向标——美国拉斯克奖概览[J]. 中国市场,2016(5):183-194.
[2] Evelyn Strauss. THE 2016 LASKER AWARDS. (2016-09-13)[2016-09-27].http://www.laskerfoundation.org/.
[3] Semenza G L, Rue E A, Iyer N V, et al. Assignment of the hypoxia-inducible factor 1alpha gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q[J]. Genomics, 1996, 34(3):437-439.
[4] Tan C C, Eckardt K U, Firth J D, et al. Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia[J]. Am J Physiol, 1992, 263(3 Pt 2):F474-F481.
[5] Tan C C, Eckardt K U, Ratcliffe P J. Organ distribution of erythropoietin messenger RNA in normal and uremic rats[J]. Kidney Int, 1991, 40(1):69-76.
[6] Ratcliffe P J, Jones R W, Phillips R E, et. al. Oxygen-dependent modulation of erythropoietin mRNA levels in isolated rat kidneys studied by RNase protection[J]. J Exp Med, 1990, 172(2):657-660.
[7] Minamishima Y A, Kaelin W J. Reactivation of hepatic EPO synthesis in mice after PHD loss[J]. Science, 2010, 329(5990):407.
[8] Sellers W R, Novitch B G, Miyake S, et al. Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth[J]. Genes Dev, 1998, 12(1):95-106.
[9] Epstein A C, Gleadle J M, McNeill L A, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation[J]. Cell, 2001, 107(1):43-54.
[10] Takeuchi K, Boonmar S, Kubo Y, et al. Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis[J]. Gene, 1990, 91(2):287-291.
[11] Kolykhalov A A, Feinstone S M, Rice C M. Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA[J]. J Virol, 1996, 70(6):3363-3371.
[12] Tsuchihara K, Hijikata M, Fukuda K, et. al. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli[J]. Virology, 1999, 258(1):100-107.
[13] Kolykhalov A A, Agapov E V, Blight K J, et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA[J]. Science, 1997, 277(5325):570-574.
[14] Yanagi M, Purcell R H, Emerson S U, et al. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee.[J]. Proceedings of the National Academy of Sciences, 1997, 94(16):8738-8743.
[15] Bartenschlager R, Lohmann V. Replication of hepatitis C virus[J]. J Gen Virol, 2000, 81(Pt 7):1631-1648.
[16] Evans M J, Rice C M, Goff S P. Genetic interactions between hepatitis C virus replicons[J]. Journal of Virology, 2004, 78(21):12085-12089.
[17] Bartenschlager R. Hepatitis C virus replicons:potential role for drug development[J]. Nature Reviews Drug Discovery, 2002, 1(11):911-916.
[18] Clark J L, Mason J C, Hollecker L, et. al. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16(6):1712-1715.
[19] Sofia M J, Furman P A, Symonds W T. Chapter 11:2'-F-2'-C-Methyl Nucleosides and Nucleotides for the Treatment of Hepatitis C Virus:from Discovery to the Clinic[J]. 2010.
[20] Lu L, Shen T, Gao J, et al. Effectiveness of HCV core antigen and RNA quantification in HCV-infected and HCV/HIV-1-coinfected patients[J]. Bmc Infectious Diseases, 2013, 14(1):1-8.
[21] Huberman J A, Kornberg A, Alberts B M. Stimulation of T4 bacteriophage DNA polymerase by the protein product of T4 gene 32.[J]. Journal of Molecular Biology, 1971, 62(1):39-52.
[22] Weintraub H, Worcel A, Alberts B. A model for chromatin based upon two symmetrically paired half-nucleosomes[J]. Cell, 1976, 9(3):409-417.