Characteristics and patterns of brain positron emission tomographic images in ischemic cerebrovascular disease using 18F-fluorodeoxyglucose and 13N-ammonia

doi:10.3969/j.issn.1006-7795.2013.01.008

Abstract

Abstract:

Objective To investigate the characteristics and patterns of brain positron emission tomography (PET) images in ischemic cerebral vascular disease (ICVD) using ¹⁸F-fluorodeoxyglucose (FDG) and ¹³N-ammonia. Methods The study included two groups of subjects: 10 normal adults and 87 patients with ICVD. The brain PET scan using ¹³N-ammonia was firstly performed and after that, ¹⁸F-FDG imaging followed. The PET images and radioactive ratios of cerebral lobes (basal ganglia and thalamus) to cerebellum were obtained. Several semiquantitative parameters were used for further analysis and they were: cerebral glucose metabolism (CGM) value, cerebral blood flow (CBF) value, decreased percent of CGM, decreased percent of CBF and the metabolism-perfusion ratio. Results 1The radioactive distribution in the normal brain was symmetrical and CGM values were greater than CBF values in every intracerebral structures. 2A total of 267 foci in 87 patients were found and 234 foci with low uptake of FDG, 189 foci with low uptake of ammonia and 2 foci with high uptake of ammonia. Only 7 foci in 7 patients were solitary lesion and the 260 foci in 80 patients displayed multiple and non-symmetrical distribution. 3Abnormal metabolism-perfusion patterns were divided into 5 types:TypeⅠ:matched type with similarly decreased CGM and CBF;Type Ⅱ:slight mismatched type with decreased CGM and normal CBF;Type Ⅲ:slight mismatched type with decreased CBF and normal CGM;Type Ⅳ:markedly mismatched type with severely decreased CGM and mildly decreased CBF;Type Ⅴ:reversed type with decreased CGM and increased CBF. Conclusion The characteristics and patterns from the combination of ¹⁸F-FDG and ¹³N-ammonia brain PET play very important roles in detection and evaluation of ICVD.

Key words: positron emission tomography, characteristics and patterns of images, ischemic cerebrovascular disease, cerebral glucose metabolism, cerebral blood flow

CLC Number:

R445

WANG Man, MA Yunchuan, JI Xunming, GAO Li, SU Yusheng, PENG Cheng, WEI Cuibai, ZHANG Linying, SHANG Jianwen. Characteristics and patterns of brain positron emission tomographic images in ischemic cerebrovascular disease using ¹⁸F-fluorodeoxyglucose and ¹³N-ammonia[J]. Journal of Capital Medical University, 2013, 34(1): 43-48.

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Characteristics and patterns of brain positron emission tomographic images in ischemic cerebrovascular disease using ¹⁸F-fluorodeoxyglucose and ¹³N-ammonia

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