Abstract: Objective To explore the application of National Electrical Manufactures Association(NEMA) NU-2 2018 Standards in equipment performance testing of positron emission tomography/computed tomography (PET/CT) system. Methods According to NEMA NU 2-2018 Standards, the performance indexes were tested, including the spatial resolution, sensitivity, scatter fraction, count loss, random measurement, timing resolution, count loss rate, random measurement correction accuracy, image quality, accuracy of attenuation and scatter correction, and image co-registration accuracy of Siemens Biograph Vision 600 PET/CT. Results The transverse and axial spatial resolution were 3.75 mm and 3.76 mm at a 1 cm offset, The sensitivity was 16.8 kcps/MBq at the center of the field of view and 16.7 kcps/MBq at a 10 cm offset from the axial of the field of view. The scatter fraction was measured at 38.58% while noise equivalent count rate peaked at 258.26 kcps corresponding to 27.37 kBq/mL.The result of timing resolution is 209.82ps. The contrast recovery of the image quality phantom ranged from 88.9% to 96.2%, and the background variability ranged from 2.05% to 6.80%, the average lung residual error was 2.43%. The maximum error of counting loss and random coincidence correction was 3.9%. At 5 cm and 100 cm from the end of the bed plate,Co-registration accuracy between PET and CT were 0.46 mm and 1.07 mm at a 1 cm offset from the Y of the center field of view, 1.06 mm and 1.45 mm at a 20 cm offset from the X of the center field of view, and 0.85 mm and 1.15 mm at a 20 cm offset from the Y of the center field of view. Conclusion The conditions of NEMA NU 2-2018 standards are closer to clinical examination and can better reflect the system performance of PET/CT equipment.

Key words: positron emission tomography/computed tomography (PET/CT), National Electrical Manufactures Association (NEMA) NU 2-2018, performance evaluation