Prediction of tumor histopathological grade using a modified peritoneal cancer index by 18F-FDG PET/CT(PET-PCI)in patients with pseudomyxoma peritonei

doi:10.3969/j.issn.1006-7795.2022.06.003

Journal of Capital Medical University ›› 2022, Vol. 43 ›› Issue (6): 834-839.doi: 10.3969/j.issn.1006-7795.2022.06.003

• Nuclear Medicine and Molecular Imaging Assists Clinical Diagnosis and Treatment • Previous Articles Next Articles

Prediction of tumor histopathological grade using a modified peritoneal cancer index by ¹⁸F-FDG PET/CT(PET-PCI)in patients with pseudomyxoma peritonei

Zhang Li¹, Li Bing², Tong Guansheng^1*

1. Department of Nuclear Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038,China,
2. Department of Peritoneal Cancer Surgery,Beijing Shijitan Hospital, Capital Medical University, Beijing 100038,China

Received:2022-09-30 Online:2022-12-21 Published:2022-11-30
Contact: ^*E-mail:tgseng@163.com

Abstract

Abstract: Objective The aim of this study was to investigate the ability of the modified peritoneal cancer index (PCI) using ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT), maximum standardized uptake value (SUVmax) and SUVmax/liver mean standardized uptake value(SUVmean_liver) to predict the histopathological grade in patients with pseudomyxoma peritonei(PMP). Methods The pathological data of 31 patients with PMP of appendiceal origin and 34 ¹⁸F-FDG PET/CT results (3 patients underwent twice examinations) from January 2017 to June 2022 were analyzed retrospectively. PET-PCI was the sum of the SUVmax scores of PMP lesions in 13 specific abdominal-pelvic regions. The SUVmax and SUVmax/SUVmean_liver of the lesion were also measured. Results There were 14 cases of low grade PMP, 12 cases of high grade PMP, and 5 cases of high grade with signet ring cells PMP. The PET-PCI, SUVmax and SUVmax/SUVmean_liver values of the high grade were higher than those of the low grade (PET-PCI:23.08 ± 7.47 vs 15.81 ± 10.59, P=0.047; SUVmax:7.91 ± 4.67 vs 6.73 ± 3.99, P=0.470; SUVmax/SUVmean_liver:3.63 ± 1.89 vs 3.17 ± 2.70, P=0.614). The PET-PCI, SUVmax and SUVmax/SUVmean_liver values of the high grade with signet ring cells were higher than those of the high grade (PET-PCI:25.20 ± 8.84 vs 23.08 ± 7.47, P=0.614; SUVmax:9.29 ± 8.46 vs 7.91 ± 4.67, P=0.660;SUVmax/SUVmean_liver:3.73±1.83 vs 3.63±1.89,P=0.917)。The values of PET-PCI, SUVmax, and SUVmax/SUVmean_liver were consistent with the PMP histopathological grade, while there was only a significant different between the PET-PCI of the high-and low-grade PMP. Conclusion Compared with SUVmax and SUVmax/SUVmean_liver, PET-PCI can better reflect the histopathological grade of PMP.

Key words: ¹⁸F-fluorodeoxyglucose, positrone emission tomography, pseudomyxoma peritonei, histopathological grade

CLC Number:

Zhang Li, Li Bing, Tong Guansheng. Prediction of tumor histopathological grade using a modified peritoneal cancer index by ¹⁸F-FDG PET/CT(PET-PCI)in patients with pseudomyxoma peritonei[J]. Journal of Capital Medical University, 2022, 43(6): 834-839.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2022.06.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2022/V43/I6/834

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Prediction of tumor histopathological grade using a modified peritoneal cancer index by ¹⁸F-FDG PET/CT(PET-PCI)in patients with pseudomyxoma peritonei

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