Effect of tight glycemia control on the clinical outcome in critically brain-injured patients: a Meta-analysis

doi:10.3969/j.issn.1006-7795.2013.02.004

Abstract

Abstract:

Objective To evaluate the effect of tight glycemia control(TGC) on the clinical outcome in critically brain-injured patients. Methods All randomized controlled trials on the use of TGC in critically brain-injured patients were identified by computer and manual retrieval. Studies were enrolled if adult patients were randomized to receive TGC or conventional glycemia control(CGC). Extracted data included mortality, long-term neurological outcome and rate of hypoglycemia. Results Sixteen trials were enrolled in this meta-analysis, 9 were published in English and 7 in Chinese. Modified Jadad scores were more than or equal to 4 in 10 trials, in which only 1 trial was published in Chinese. There were no significant differences in hospital mortality or late mortality between TGC and CGC groups. The rate of hypoglycemia was higher in TGC group. The combined rate of good long-term neurological outcome was significantly higher in survived patients receiving TGC(odd ratio=1.37, 95% confidence interval: 1.05~1.80). Conclusion TGC was beneficial at improving long-term neurological outcome in critically brain-injured patients. The quality of randomized controlled trials published in Chinese should be further improved.

Key words: tight glycemia control, critically brain injury, randomized controlled trial

CLC Number:

R651.1⁺5

YIN Ningning, YUE Xiaoyan, CAI Yehua, ZHOU Jianxin. Effect of tight glycemia control on the clinical outcome in critically brain-injured patients: a Meta-analysis[J]. Journal of Capital Medical University, 2013, 34(2): 181-186.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.02.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I2/181

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