This study was awarded with The Second Grade National Prize for Science and Technology Progress—The application study on epidemiology, pathogenesis, diagnosis and treatment of mild cognitive impairment and dementia

doi:10.3969/j.issn.1006-7795.2014.01.001

Abstract

Abstract:

Dementia and mild cognitive impairment are the most common neurodegenerative disease and the leading cause of dementia in the elderly. Sponsored by over 40 national and provincial funds, we have obtained tremendous achievements through all these years hard work, which included: (1) A large complete system of clinical information and biological specimen dataset of dementia and mild cognitive impairment of Chinese population. (2) The study confirmed the genetic/susceptibility genes and major protein functions associated with Alzheimer's disease(AD) and reported for the first time the novel presenilin 1(V97L and A136G) mutation and SNPs in over 20 susceptibility genes associated with sporadic AD in Chinese population. (3) The study identified and confirmed the biomarkers and images for early diagnosis of AD. (4) The guidelines for the diagnosis and treatment of dementia and cognitive disorders. (5) New drugs for AD were developed and the technology platform for drug was constructed. This project improved the diagnostic and treatment skills for dementia and mild cognitive disorders and achieved significant social benefits.

Key words: mild cognitive disorders, dementia, Alzheimer's disease(AD), drug, diagnosis and treatment

CLC Number:

R741

Jia Jianping. This study was awarded with The Second Grade National Prize for Science and Technology Progress—The application study on epidemiology, pathogenesis, diagnosis and treatment of mild cognitive impairment and dementia[J]. Journal of Capital Medical University, 2014, 35(1): 1-5.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.01.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I1/1

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