Progress in T follicular helper cells and their related immune disease studies

doi:10.3969/j.issn.1006-7795.2014.04.025

Abstract

Abstract:

T follicular helper cells(Tfh cells) are newly defined as a new subset of CD4⁺ T cells, which are responsible for assisting B cells to produce antibodies. And its main function is to contribute to the activation, proliferation and differentiation of B cells, and then form germinal centers. The major function molecules of Tfh cells such as C-X-C chemokine receptor type 5(CXCR5), inducible co-stimulator(ICOS), interleukin 21(IL-21) and B-cell CLL/lymphoma 6(Bcl-6), are involved in the differentiation of Tfh cells. The number of Tfh cells and the abnormalities of its functional molecules are associated with autoimmune diseases which are mediated by a variety of autoantibodies.

Key words: T follicular helper cells, immune diseases, interleukin 21, B-cell CLL/lymphoma 6

CLC Number:

R593.2

Liu Yan, Wan Suigui. Progress in T follicular helper cells and their related immune disease studies[J]. Journal of Capital Medical University, 2014, 35(4): 507-510.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.04.025

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I4/507

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