A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

doi:10.3969/j.issn.1006-7795.2015.01.018

Journal of Capital Medical University ›› 2015, Vol. 36 ›› Issue (1): 94-97.doi: 10.3969/j.issn.1006-7795.2015.01.018

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A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

Wu Xiaojuan¹, Zhuang Xiaoming¹, He Yueming², Sheng Shuli³

1. Department of Endocrinology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;
2. Department of Radiology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;
3. Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

Received:2014-09-01 Online:2015-02-21 Published:2015-01-31
Supported by:
This study was supported by Xicheng District, Beijing Science and Technology Project(2012JH29).

Abstract

Abstract: Objective To investigate the working memory in the patients with impaired glucose tolerance (IGT) by functional magnetic resonance imaging (fMRI). Methods Verbal and objective working memory tasks were performed in 13 patients with IGT and 19 persons with normal glucose tolerance (NGT) while performing fMRI. The cognitive function, memory function and the activation map were analyzed.Results ① There was no significant difference in cognition function between the NGT and IGT group (t=0.459, P=0.635). ②Compared with NGT group, there was less activation of right temporal and superior temporal gyrus (BA22) area in IGT group during word working memory; less activation of right putamen, lenticular body in IGT group during number working memory; less activation of right caudate body in IGT group during object working memory (P<0.01). Conclusion IGT group may have lesions in the classic activation areas during verbal working memory and object memory.

Key words: impaired glucose tolerance, working memory, functional magnetic resonance imaging

CLC Number:

Wu Xiaojuan, Zhuang Xiaoming, He Yueming, Sheng Shuli. A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique[J]. Journal of Capital Medical University, 2015, 36(1): 94-97.

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A study on working memory of patients with impaired glucose tolerance by functional magnetic resonance imaging technique

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