Journal of Capital Medical University ›› 2015, Vol. 36 ›› Issue (2): 212-218.doi: 10.3969/j.issn.1006-7795.2015.02.010

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Persistence and clearance high risk human papillomavirus types in the population of primary infection: a follow-up study

Xu Shasha1, He Xin1, Liu Yingqiao2, Liu Jun1, Wang Shenzhen1, Wang Yue3, Diao Xiaoli3, Qu Jiuxin4   

  1. 1. Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
    2. Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China;
    3. Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China;
    4. Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
  • Received:2014-12-28 Online:2015-04-21 Published:2015-04-16
  • Supported by:
    This study was supported by Natural Science Foundation of Beijing(7122069), Scientific Project of Beijing Municipal Science and Technology Commission(Z131100004013018), Seed Funding of Beijing Jinqiao Project(2014-2016).

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Abstract: Objective To investigate the persistence and clearance data regarding the 13 types of high risk human papillomavirus(HR-HPV) in the population of primary infection. Methods A total of 969 cases of HR-HPV positive patients were followed up between January 1, 2013 and December 31, 2013. The epidemiological characteristics of HR-HPV persistent infection were analyzed. The age, viral genotyping, HR-HPV multiple genotypes and initial viral load were evaluated. Statistical analyses were performed using SPSS software for Windows (version 18.0). The Kaplan-Meier survival function was used for calculating the time taken for the clearance of HR-HPV. The role of a group of independent variables concerning the time taken until clearance was evaluated using a Cox proportional-hazards regression model. P<0.05 was considered statistically significant. Results The average time of viral clearance was 9.52 months for all of 969 cases(9.09-9.95 months 95% CI). Older women had longer clearance time than the younger women groups(χ2=7.63, P=0.45). It was found that HPV-56, 35, 58, 52 and 18 had the lower probability of being cleared, when that HPV-45, 51 and 68 had the shorter time to be cleared. It was also found that multiple viral infection had the lower probability of being cleared than the single ones(χ2=18.67, P=0.000). Lower viral loads had better clearance compared to those having higher viral loads(χ2=18.68, P=0.000)). It was shown that age (regression coefficient=-0.082, P=0.046)and single or multiple HR-HPV infection (regression coefficient=-0.231, P=0.037) were associated with time to clearance in the present sample, while the lower or higher viral loads (regression coefficient=-0.185, P=0.108) was not associated with time to clearance in the Cox proportional-hazards regression model. Conclusion HPV infection clearance in this study was related to factors such as age, infection type, viral load and the multiple or single viral infections.

Key words: high risk human papillomavirus(HR-HPV), persistence, clearance time, viral load

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