Epidemiologic characteristics of high risk human papillomavirus(HR-HPV) infection in population undergone hospital opportunistic health screening and the relationship between cervical cancer lesion and HR-HPV infection
He Xin, Tao Huicheng, Liu Chen, Wang Shuzhen, Wang Yue, Diao Xiaoli, Qu Jiuxin
2015, 36(2):
219-225.
doi:10.3969/j.issn.1006-7795.2015.02.011
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Objective To study epidemiological characteristics of population who underwent opportunistic screening for high risk-human papillomavirus(HR-HPV) infection, and to explore the relationship between HR-HPV infection and cervical precancerous lesions. Methods Data from 2 305 patients, according the inclusion criteria, who underwent HR-HPV DNAs and cervical cytology tests at the outpatient department of OB & GYN, Beijing Chaoyang Hospital from January 1, 2012 to December 31, 2012, were collected. HR-HPV DNAs were detected by hybrid capture-Ⅱ(HC-Ⅱ) method, cervical exfoliated cells were collected and inspected. SPSS 18.0 software was used for statistical analysis. Results 1) The infection rate of HR-HPV of the screening crowd was 34.84%, of which the young women(20-24 years old) is the highest(50.0%). With aging, the rate decreased gradually, the lowest rate of women aged 45-49 years(24.18%). It increased again after the age of 55 years(47.02%), showing second peak of infection. The age distribution of positive rate of cervical cytology tests also had two peaks, consistent with characteristics of age distribution of HR-HPV infection rate. 2) HR-HPV infection rates were respectively 23.98%, 66.47%, 87.21%, 98.04% and 100% in normal or inflammation, atypical squamous cells undetermined significance(ASCUS), low squamous intraepithelial lesion(LSIL), high squamous intraepithelial lesion(HSIL), squamous of cervical carcinoma(SCC), thin preparation test(TCT) results, respectively. HR-HPV infection rates of subjects with normal cervical biopsy or inflammation, cervical intraepithelial lesions(CIN)-Ⅰ, CIN-Ⅱ, CIN-Ⅲ, ASCUS, LSIL, HSIL and SCC were 67.44%, 86.96%, 88.24%, 94.57%, 90.48%, respectively. With the increasing level of cervical cytology lesions and cervical histological lesions, the rate of HR-HPV infection significantly increased. 3) In ASCUS patients, the incidence of high-grade cervical lesions was 31.73%, which in HR-HPV positive group was 36.93% and in negative group was 21.43%. The difference was statistically significant between the two groups(χ2=4.13, P=0.042). 4) In LSIL patients, the incidence of high-grade cervical lesions was 34.40%, which in HR-HPV positive group was 37.37% and in negative group was 14.29%. The difference was statistically significant between the two groups(χ2=5.76, P=0.016). Conclusion The infection rate of HR-HPV and the abnormal rate of cervical cytology are different with different age. Younger than 24 years and ≥ 55 years were peak of both of HR-HPV infection and abnormal cytology. HR-HPV infection and cervical lesion severity was positively correlated. Patients for ASCUS and LSIL of cervical cytology, if HR-HPV positive, will increase the probability of CIN-Ⅱ and above lesions, but negative patients cannot be excluded from high-grade cervical lesions, the colpscopic examination is necessary.
