Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

doi:10.3969/j.issn.1006-7795.2015.02.022

Abstract

Abstract:

Objective To exactly analyze low density lipoprotein(LDL) subclass and examine the association between small dense LDL(sdLDL) and corneal arcus in young patients. Methods We selected 12 cases of young patients with corneal arcus and normal serum lipids. Another 12 control cases with matched age, gender, smoking were recruited from Beijing Anzhen Hospital between March 2014 and October 2014. LDL particle separation was performed by Lipoprint System: LDL subfractions were obtained and sdLDL proportion(% of sdLDL particles) was calculated. sdLDL% was compared with the Student t test between two groups. Logistic regression analysis was performed to evaluate the correlation between corneal arcus and its related factors. Results SdLDL% was increased in corneal arcus group compared with controls[(19.64±6.52)% vs (13.16±6.29)%]. The difference between the two groups was significant(P=0.020). SdLDL% was significantly associated with corneal arcus(P=0.040) after controlling for age and LDL. SdLDL% played a role in the development of corneal arcus(OR=1.49, 95% CI: 1.01-2.19, P<0.05). Conclusion These findings suggested that young patients with corneal arcus and normal serum lipids had increased level of sdLDL proportion, indicating the abnormality of LDL subclass in such cases.

Key words: corneal arcus, Lipoprint LDL System, small dense low density lipoprotein

CLC Number:

R446

Gao Xinxiao, Guo Jia, Lin Jie, Meng Xin, Wang Jun. Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids[J]. Journal of Capital Medical University, 2015, 36(2): 287-290.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.02.022

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I2/287

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