Significance of the detection of anti-neuronal antibodies in the diagnosis of paraneoplastic syndrome of nervous system

doi:10.3969/j.issn.1006-7795.2016.04.015

Abstract

Abstract: Objective To evaluate the significance of the detection of anti-neuronal antibodies in the early diagnosis of paraneoplastic syndrome (PNS) of nervous system (PNSNS). Methods We detected anti-Hu, anti-Yo, anti-Ri, anti-Ma2/ta, anti-CV2, anti-Amphiphysin antibodies of 68 sera by neuronal antigen spectrum of IgG antibody kit (amount medical laboratory diagnostics ag); Results Of the 48 PNS samples, 6 (6/48, 12.5%) were positive for anti-neuronal autoantibodies, among which, 4(23.5%) positive samples were from Group A (demyelinating diseases), 2 (10.0%) positive samples were from Group C (Guillain-Barre syndrome); samples from Group B (motor neuron diseasse) and D (Healthy control) were all negative. There was a trend of higher ratio of anti-neuronal antibodies positive rate in PNSNS group than healthy control group, although the data failed to reach a statistical significance. Conclusion The detection of anti-neuronal antibodies might be a credible method in the early diagnosis of PNSNS.

Key words: paraneoplastic syndrome of nervous system (PNSNS), anti-neuronal antibodies, demyelinating disease

CLC Number:

R446.1

Lyu Hong, Wu Yuan, Wang Lijuan, Zhang Guojun. Significance of the detection of anti-neuronal antibodies in the diagnosis of paraneoplastic syndrome of nervous system[J]. Journal of Capital Medical University, 2016, 37(4): 491-494.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2016.04.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2016/V37/I4/491

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