Antibiotic resistance and serotype distribution of group B Streptococci in pregnant women in Beijing

doi:10.3969/j.issn.1006-7795.2018.04.021

Journal of Capital Medical University ›› 2018, Vol. 39 ›› Issue (4): 591-595.doi: 10.3969/j.issn.1006-7795.2018.04.021

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Antibiotic resistance and serotype distribution of group B Streptococci in pregnant women in Beijing

Li Dong, Zhang Shuchen, Shi Yanli, Li Xueqing, Lu Binghuai

Department of Laboratory Medicine, Civil Aviation General Hospital, Beijing 100123, China

Received:2017-10-16 Online:2018-07-21 Published:2018-07-21
Supported by:
This study was supported by Beijing Municipal Science & Technology Commission of China(Z141107002514036, Z171100001017118).

Abstract

Abstract: Objective To investigate the molecular epidemiological characteristics of group B Streptococci (GBS) isolated from pregnant women in Beijing, and the antibiotic profiles of the microorganism.Methods A total of 96 GBS isolates were collected from vaginal/rectal swabs in pregnant women admitted to Civil Aviation General Hospital and Bejing Huafu Women & Children's Hospital from July 2016 to June 2017. PCR methods were used to analyze the serotypes and antibiotic genes. Antibiotic susceptibility tests were performed on common antibiotics against GBS. Results The most common serotypes were Ⅲ (40 strains, 41.7%), Ia (13 strains, 13.5%), and V (18 strains, 18.8%) respectively. And all strains were sensitive to penicillin, ampicillin, vancomycin and cefotaxime. However, 71% (68 strains) GBS were resistant to erythromycin, 69% (66 strains) were resistant to clindamycin. The erythromycin resistance was mainly associated with the ermB gene; 81.4% of the erythromycin resistant strains carried the gene. Conclusion The GBS strains in Beijing area have similar molecular epidemiological features to other countries around the world, but having its own characteristics.

Key words: antibiotic resistance, group B Streptococcus, serotype

CLC Number:

R446.11

Li Dong, Zhang Shuchen, Shi Yanli, Li Xueqing, Lu Binghuai. Antibiotic resistance and serotype distribution of group B Streptococci in pregnant women in Beijing[J]. Journal of Capital Medical University, 2018, 39(4): 591-595.

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References

[1] Kim E J, Oh K Y, Kim M Y,et al. Risk factors for group B streptococcus colonization among pregnant women in Korea[J]. Epidemiol Health, 2011, 33:e2011010.
[2] Verani J R, McGee L, Schrag S J. Division of bacterial diseases, national center for immunization and respiratory diseases, centers for disease control and prevention (CDC). prevention of perinatal group B streptococcal disease-revised guidelines from CDC, 2010[J]. MMWR Recomm Rep, 2010, 59(RR-10):1-36.
[3] Lu B, Li D, Cui Y, et al. Epidemiology of group B streptococcus isolated from pregnant women in Beijing, China[J]. Clin Microbiol, 2014, 20(6):O370-373.
[4] Imperi M, Pataracchia M, Alfarone G, et al. A multiplex PCR assay for the direct identification of the capsular type (Ia to IX) of Streptococcus agalactiae[J]. J Microbiol Methods,2010, 80(2):212-214.
[5] Poyart C, Tazi A, Reglier-Poupet H, et al. Multiplex PCR assay for rapid and accurate capsular typing of group B streptococci[J]. J Clin Microbiol,2007, 45(6):1985-1988.
[6] Lu B, Chen X, Wang J, et al. Molecular characteristics and antimicrobial resistance in invasive and noninvasive Group B Streptococcus between 2008 and 2015 in China[J]. Diagnostic Microbiol Infectious Dis,2016, 86(4):351-357.
[7] Clinical and Laboratory Standards Institute.Performance Standards for Antimicrobial Susceptibility Testing. Twenty-Seventh Informational Supplement,M100[S].Pennsylvavnia:Clinical and Laboratory Standards Institute, 2017.
[8] Kwatra G, Cunnington M C, Merrall E,et al. Prevalence of maternal colonisation with group B streptococcus:a systematic review and meta-analysis[J]. Lancet Infect Dis,2016, 16(9):1076-1084.
[9] Joubrel C, Tazi A, Six A, et al. Group B streptococcus neonatal invasive infections, france 2007-2012[J]. Clin Microbiol, 2015, 21(10):910-916.
[10] Seo Y S, Srinivasan U, Oh KY, et al. Changing molecular epidemiology of group B streptococcus in Korea[J]. J Korean Med Sci,2010, 25(6):817-823.
[11] Chaudhary M, Edwards M S. Group B streptococcus:An emerging infection in south asia[J]. Int J Infect Dis,2016, 45:168-169.
[12] Morozumi M, Wajima T, Takata M, et al. Molecular characteristics of group B streptococci isolated from adults with invasive infections in Japan[J]. J Clin Microbiol,2016, 54(11):2695-2700.
[13] 张树琛,王杉,朱凤霞,等.B群链球菌显色培养基在孕产妇B群链球菌筛查中的性能评价[J].首都医科大学学报,2016,37(5):680-683.
[14] 王振荣,高春燕,李宜学.孕妇生殖道无乳链球菌感染的临床分析[J].中国煤炭工业医学杂志,2017,20(3):266-268.
[15] 侯向萍,秦旭红,龚河军,等.新疆阿拉尔地区耐红霉素葡萄球菌对克林霉素诱导耐药性的研究[J].临床误诊误治,2015,(10):72-76.

Antibiotic resistance and serotype distribution of group B Streptococci in pregnant women in Beijing

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