Abstract: Objective The objective of this study was to investigate the clinicopathological characteristics of ulcerative gastrointestinal stromal tumor with hemorrhage. Methods The clinicopathological data of patients of ulcerative gastrointestinal stromal tumor with hemorrhage in our hospital during 2015 to 2017 were retrospectively analyzed. Patients of gastrointestinal stromal tumor without ulcer or hemorrhage were collected as control. Results Totally 21 patients of ulcerative gastrointestinal stromal tumor with hemorrhage including 14 (66.7%) males and 7 (33.3%) females were evaluated for the clinicopathological characteristics. All of the patients received gastroscopic and endoultrasonographic examination prior to surgery. The tumor size ranged from 3 to 18 cm. Of these, 71.4% (15/21) was larger than 5 cm(95% CI:48-89). CD117 and DOG1 were positive in 100% (21/21), while CD34 was positive in 95.2% (20/21). Mitotic index was more than 5/50 HPF in 42.9% (9/21). Ki-67 poistives were more than 5% in 66.7% (14/21). 81% of cases belonged to the middle-high grade risk category. In the same period, 619 patients were diagnosed as gastrointestinal stromal tumor without ulcer or hemorrhage by using gastroscope and endoscopic ultrasonography. The tumor size ranged from 0.3 to 7 cm. Of these, 1.9% (12/619) was larger than 5 cm. Conclusion Most of the ulcerative gastrointestinal stromal tumors with hemorrhage were big tumors and belonged to the middle-high grade risk category.

Key words: astrointestinal stromal tumor, mitotic index, gastrointestinal hemorrhage, endoscopic ultrasonography