Epidemiologic characteristics of high risk human papillomavirus(HR-HPV) infection in population undergone hospital opportunistic health screening and the relationship between cervical cancer lesion and HR-HPV infection

doi:10.3969/j.issn.1006-7795.2015.02.011

Abstract

Abstract: Objective To study epidemiological characteristics of population who underwent opportunistic screening for high risk-human papillomavirus(HR-HPV) infection, and to explore the relationship between HR-HPV infection and cervical precancerous lesions. Methods Data from 2 305 patients, according the inclusion criteria, who underwent HR-HPV DNAs and cervical cytology tests at the outpatient department of OB & GYN, Beijing Chaoyang Hospital from January 1, 2012 to December 31, 2012, were collected. HR-HPV DNAs were detected by hybrid capture-Ⅱ(HC-Ⅱ) method, cervical exfoliated cells were collected and inspected. SPSS 18.0 software was used for statistical analysis. Results 1) The infection rate of HR-HPV of the screening crowd was 34.84%, of which the young women(20-24 years old) is the highest(50.0%). With aging, the rate decreased gradually, the lowest rate of women aged 45-49 years(24.18%). It increased again after the age of 55 years(47.02%), showing second peak of infection. The age distribution of positive rate of cervical cytology tests also had two peaks, consistent with characteristics of age distribution of HR-HPV infection rate. 2) HR-HPV infection rates were respectively 23.98%, 66.47%, 87.21%, 98.04% and 100% in normal or inflammation, atypical squamous cells undetermined significance(ASCUS), low squamous intraepithelial lesion(LSIL), high squamous intraepithelial lesion(HSIL), squamous of cervical carcinoma(SCC), thin preparation test(TCT) results, respectively. HR-HPV infection rates of subjects with normal cervical biopsy or inflammation, cervical intraepithelial lesions(CIN)-Ⅰ, CIN-Ⅱ, CIN-Ⅲ, ASCUS, LSIL, HSIL and SCC were 67.44%, 86.96%, 88.24%, 94.57%, 90.48%, respectively. With the increasing level of cervical cytology lesions and cervical histological lesions, the rate of HR-HPV infection significantly increased. 3) In ASCUS patients, the incidence of high-grade cervical lesions was 31.73%, which in HR-HPV positive group was 36.93% and in negative group was 21.43%. The difference was statistically significant between the two groups(χ²=4.13, P=0.042). 4) In LSIL patients, the incidence of high-grade cervical lesions was 34.40%, which in HR-HPV positive group was 37.37% and in negative group was 14.29%. The difference was statistically significant between the two groups(χ²=5.76, P=0.016). Conclusion The infection rate of HR-HPV and the abnormal rate of cervical cytology are different with different age. Younger than 24 years and ≥ 55 years were peak of both of HR-HPV infection and abnormal cytology. HR-HPV infection and cervical lesion severity was positively correlated. Patients for ASCUS and LSIL of cervical cytology, if HR-HPV positive, will increase the probability of CIN-Ⅱ and above lesions, but negative patients cannot be excluded from high-grade cervical lesions, the colpscopic examination is necessary.

Key words: high risk-human papillomavirus(HR-HPV), epidemiology, cervical intraepithelial neoplasia

CLC Number:

R711.74

He Xin, Tao Huicheng, Liu Chen, Wang Shuzhen, Wang Yue, Diao Xiaoli, Qu Jiuxin. Epidemiologic characteristics of high risk human papillomavirus(HR-HPV) infection in population undergone hospital opportunistic health screening and the relationship between cervical cancer lesion and HR-HPV infection[J]. Journal of Capital Medical University, 2015, 36(2): 219-225.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.02.011

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I2/219

References

[1] 郎景和.子宫颈癌预防的现代策略[J].中国医学科学院学报,2007,29(5):575-578.
[2] Bao Y P, Li N, Smith J S, et al. Human papillomavirus type-distribution in the cervix of Chinese women:a meta-analysis[J]. Int J STD AIDS, 2008,19(2):106-111.
[3] Cogliano V, Baan R, Straif K, et al. Carcinogenicity of Human papillomaviruses[J]. Lancet Oncol, 2005,6(4):204.
[4] Pinto L A, Viscidi R, Harro C D, et al. Cellular immune responses to UPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles[J]. Virology, 2006,353(2):451-462.
[5] 李静然,魏丽惠.子宫颈癌筛查研究新进展研讨会纪要[J].中国妇产科临床杂志,2013,14(4):370-371.
[6] 刘春燕,卞美璐,等.高危型人乳头瘤病毒第二代杂交捕获试验筛查宫颈癌及其癌前病变的验证研究[J].中国肿瘤,2009,18(12):77-80.
[7] Martinez S B, Palomares J C, Artura A, et al. Comparison of cobas 4800 human papillomavirus test against acombination of the amplacor human papillomavirus and the linear arraytests for detection of HPV types 16 and 18 in cervical samples[J]. J Virol Methods, 2012,180(1-2):7-10.
[8] 赵方辉,李楠,马俊飞,等.山西襄垣妇女HPV感染与宫颈癌的研究[J].中华流行病学杂志,2001,22(5):375-378.
[9] 乔友林,章文华,李凌,等.山西子宫颈癌筛查方法的横断面研究[J].中国医学科学院学报,2002,24(1):50-53.
[10] 薛晓玲,党蓉芳,张朝红,等.宝鸡地区宫颈癌筛查方案的可行性研究[J].中国煤炭工业医学杂志,2014,17(5):794-796.
[11] Bosch F X, Lorincz A, Munoz N, et al. The causal relation between human papillomavirus and cervical cancer[J]. J Clin Pathol, 2002,55(4):244-265.
[12] Pham T H, Nguyen T H, Herrero R, et al. Human papilloma virus infection among women in South and North Vietnam[J]. Int J Cancer, 2003,104(2):213-220.
[13] 白娣斯,马冬,李鸥.唐山地区汉族妇女IL-10-1082基因多态性与HPV16、18相关性宫颈癌的研究[J].中国煤炭工业医学杂志,2012,15(8):1147-1149.
[14] Dar A A, Majid S, Nosrati M, et al. Functional modulation of IGF-binding protein 3 expression in melanoma[J]. J Invest Dermatol, 2010,130(8):2071-2079.
[15] 常小垒,郭科军,张颐.HPV亚型与子宫颈癌前病变及癌变的关系探讨[J].中国医科大学学报,2014,43(8):720-723, 727.
[16] 宋菁华,王克芳,李斌,等.人宫颈癌侧群细胞的分选及其生物学特性的研究[J].首都医科大学学报,2012,33(1):5-10.
[17] Hong D, Ye F, Chen H, et al. Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China[J]. Jnt J Gynecol Cancer, 2008,18(1):104-109.
[18] Song S H, Lee J K, Seok O S, et al. The relationship between cytokines and HPV-16, HPV-16 E6, E7, and high-risk HPV viral load in the uterine cervix[J]. Gynecol Oncol, 2007,104(3):732-738.
[19] Qu Y, Dang S, Hou P. Gene methylation in gastric cancer[J]. Clin Chim Acta, 2013,424(10):53-65.
[20] Acos Committee on Practice Bulletins-Gynecology. ACOG practice bulletin No. 109, cervical cytologyscreening[J]. Obstet Gynecol, 2009,114(6):1409-1420.