Abstract:

Objective To measure the minimum alveolar concentration (MAC EI₅₀ and EI₉₅) of sevoflurane during intubation with Tosight video larygoscope in neonates. Methods Twenty-two ASAⅠor Ⅱ infants under operations in general anesthesia were induced by sevoflurane. Initial concentration is set to 3.3%, the adjacent concentration ratio is 1.1.The concentration of sevoflurane was determined via the modified Dixon's up-and-down method (a level as a step size). After equilibrium between blood and brain concentration of sevoflurane, the trachea was intubated. Probit analysis was used for calculating MAC EI₅₀, EI₉₅ and 95% confidence interval (95%CI). Results The MAC EI₅₀ of sevoflurace was 3.65% (95%CI : 3.28%-4.04%) and EI₉₅ of sevoflurace was 4.24% (95%CI : 3.93%-7.14%). Conclusion The MAC EI₅₀ and EI₉₅ of sevoflurane during Tosight video laryngoscope intubation in neonates were 3.65% and 4.24%.

Key words: Tosight video laryngoscope, sevoflurance, neonates, the modified Dixon's up-and-down method