Value of laboratory indicators for clinical diagnosis and treatment of the patients with severe hand, foot and mouth disease complicated with Mycoplasma pneumoniae infection

doi:10.3969/j.issn.1006-7795.2015.04.017

Abstract

Abstract:

Objective To investigate the value of laboratory indicators in clinical diagnosis and treatment of the patients with severe hand, foot and mouth disease(HFMD) commplicated with enterovirus 71(EV71) and Mycoplasma pneumoniae infection. Methods The data of 100 cases with HFMD and 50 cases with non-HFMD were collected in Beijing Ditan Hospital from March 2014 to August 2014. Real-time fluorescence quantitative PCR(RT-PCR) method was used to test the DNA in stool samples and obtained qualitative results. Passive agglutination test was performed to detect Mycoplasma pneumoniae antibody titers in serum. Then, we analyzed the possibility of Mycoplasma pneumoniae infection in HFMD group and non-HFMD group, and explored the correlation of EV71 infection complicated with Mycoplasma pneumoniae infection and the severity of HFMD. Results The positive rate of Mycoplasma pneumoniae infection in the severe HFMD group(76%) was significantly higher than that in the mild HFMD group(48%, χ²=8.319, P=0.004). Conclusion Close teention should be paid to severe HFMD patients with the EV71 infection complicated with Mycoplasma pneumoniae infection. This is critically important for reducing the severity of HFMD.

Key words: severe hand foot and mouth disease, enterovirus 71, Mycoplasma pneumoniae, concurrent infection

CLC Number:

R446

Qu Pei, Xu Xinmin, Zhao Miaomiao, Li Juan, Song Shujing, Guo Jie, Hua Wenhao. Value of laboratory indicators for clinical diagnosis and treatment of the patients with severe hand, foot and mouth disease complicated with Mycoplasma pneumoniae infection[J]. Journal of Capital Medical University, 2015, 36(4): 601-603.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.04.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I4/601

References

[1] Richardson H B Jr, Leibovitz A. "Hand, foot and mouth disease" in children: an epidemic associated with coxsackie virus A-16[J]. J Pediatr, 1965,67:6-12.
[2] 陆国平,李兴旺,吕勇,等.危重症手足口病(EV71感染)诊治体会[J].中国小儿急救医学,2008,15(3):217-220.
[3] 杜开先,张艳,贾天明,等.儿童重症手足口病治疗的体会[J].医学与哲学,2011,32(5):69-69.
[4] Li Y, Dang S, Deng H, et al. Breastfeeding, previous Epstein-Barr virus infection, Enterovirus 71 infection, and rural residence are associated with the severity of hand, foot, and mouth disease[J]. Eur J Pediatr, 2013,172(5):661-666.
[5] 中华人民共和国卫生部.手足口病诊疗指南(2010年版)[EB/OL].http://www.nhfpc.gov.cn/yzygj/s3593g/201306/6d935c0f43cd4a1fb46f8f71acf8e245.shtml.
[6] 中华人民共和国国家卫生和计划生育委员会.2014年7月全国法定传染病疫情概况[EB/OL].http://www.chinacdc.cn/tjsj/fdcrbbg/201408/t20140827_101835.htm.
[7] 顾红岩,李兴旺. EV71和CoxA16 病毒的区别与联系[J].中华实验和临床感染病杂志:电子版,2014,8(1):132-136.
[8] 刘虹,王春妍.手足口病患儿免疫功能临床分析[J].天津医科大学学报,2009,15(3):503-504.
[9] Gilbert G L, Dickson K E, Waters M J, et al. Outbreak of enterovirus 71infection in Victoria, Australia, with a high incidence of neurologic involvement[J]. Pediatr Infect Dis J, 1988,7(7):484-488.
[10] 吴清岩.重症手足口病330例临床分析[J].中国煤炭工业医学杂志,2012,15(12):1862-1864.
[11] Chen S P, Huang Y C, Li W C, et al. Comparison of clinical features between coxsackievirus A2 and enterovirus 71 during the enterovirus outbreak in Taiwan, 2008 A children's hospital experience[J]. J Microbiol Immunol Infect, 2010,43(2):99-104.
[12] 田玲,汪楠,张宏梁,等.手足口病(EV71)防治[J].首都医科大学学报,2008,29(3):253-256.

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