Journal of Capital Medical University ›› 2015, Vol. 36 ›› Issue (4): 645-648.doi: 10.3969/j.issn.1006-7795.2015.04.026

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Effects of TongXie-YaoFang formula on serotonin and chromogranin a related transport mechanism of ion channels in colonic mucosa in diarrhea-predominant irritable bowel syndrome

Zhang Shengsheng, Yang Cheng   

  1. Center for Digestive Disease, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • Received:2012-02-11 Online:2015-08-21 Published:2015-07-17
  • Supported by:

    This study was supported by National Natural Science Foundation of China(81473644), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX201411), Project of Health Technical Personnel of Beijing Health System(2011-2-13).

Abstract:

Diarrhea-predominant irritable bowel syndrome(D-IBS) is a clinically common functional intestinal disease and it brings inconvenience to patients' live and work. TongXie-YaoFang(TXYF) formula, as a famous ancient prescription of Traditional Chinese Medicine, can significantly reduce the abdominal pain and diarrhea of D-IBS patients, thereby to improve the quality of their live and work. However, the exact mechanism is unclear. This article explores the influence of TXYF formula on ion channels of colon mucous membrane in D-IBS from the perspective of 5-HT and chromogranin A(CGA) related ion channel transport mechanism in order to provide reliable basis for subsequent clinical and basic research.

Key words: TongXie-YaoFang(TXYF) formula, diarrhea-predominant irritable bowel syndrome(D-IBS), serotonin(5-HT), chromogranin A, ion channels, colonic mucosa

CLC Number: