Based on the impact of magnolol on Candida albicans adhesion and biofilm formation for exploring its anti-caries effect

doi:10.3969/j.issn.1006-7795.2015.06.019

Journal of Capital Medical University ›› 2015, Vol. 36 ›› Issue (6): 942-945.doi: 10.3969/j.issn.1006-7795.2015.06.019

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Based on the impact of magnolol on Candida albicans adhesion and biofilm formation for exploring its anti-caries effect

Xiang Xiaobo¹, Zhou Yanmeng², Feng Linying³, Dong Hua⁴

1. Department of Stomatological Surgery, Affiliated Stomatology Hospital of Zunyi Medical College, Zunyi 563000, Guizhou Province, China;
2. Department of Microbiology and Immunology, Zunyi Medical University, Zunyi 563000, Guizhou Province, China;
3. Grade 2011 of the Medicine & Technology School, Zunyi Medical University, Zunyi 563000, Guizhou Province, China;
4. Grade 2012 of the Medicine & Technology School, Zunyi Medical University, Zunyi 563000, Guizhou Province, China

Received:2015-09-28 Online:2015-12-21 Published:2015-12-18
Supported by:
This study was supported by Projects of Administration of Traditional Chinese Medicine by Guizhou Province(ky2015-9).

Abstract

Abstract: Objective To observe the impact of magnololon Candida albicans adhesion and biofilm formation in order to assess its anti-caries effect. Methods Through 96-well microtiter plate copy C.albicans in vitro adhesion and biofilm model, XTT reduction assay was applied to evaluate the effect of the different concentrations of magnolol on C.albicans adhesion and biofilm formation. Results Magnolol has inhibitory effect on C. albicans adhesion, its action has the time and the concentration dependence. The magnolol of 62.5 mg/L and 125 mg/L of magnolol had significantly inhibited adhesion of C. albicans, compared with the negative control group, the difference was statistically significant(P < 0.05). Test the concentration of the selected five magnolol had different degrees of inhibition on C. albicans biofilms, of which the inhibition rates of 125 mg/L magnolol against C. albicans biofilm was 66.32%. Conclusion Magnolol can inhibit adhesion of C. albicans and reduce its pathogenicity, and has obvious inhibitory effect to the formed biofilm. The results suggest magnolol has a good application prospect as an anti-caries drug.

Key words: magnolol, candida albicans, dental caries

CLC Number:

R988.2

Xiang Xiaobo, Zhou Yanmeng, Feng Linying, Dong Hua. Based on the impact of magnolol on Candida albicans adhesion and biofilm formation for exploring its anti-caries effect[J]. Journal of Capital Medical University, 2015, 36(6): 942-945.

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Based on the impact of magnolol on Candida albicans adhesion and biofilm formation for exploring its anti-caries effect

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