Exploring therapeutic mechanisms of traditional Chinese medicine Tongfu granule in preventing sepsis-induced intestinal dysmotility

doi:10.3969/j.issn.1006-7795.2015.03.032

Abstract

Abstract:

Intestinal dysmotility is the frequent complications in patients with sepsis. Our epidemiological investigation from 37 hospitals in China showed that the incidence of gastrointestinal dysfunction in the severe sepsis patients were 78.8 %. During treatment of gastrointestinal dysfunction in patients with multiple organ dysfunction syndrome (MODS), Tongfu granule (Chinese patents 200710122532.2) treatment was found to enhance the intestinal motility, lower the activity of plasma diamine oxidase (DAO) and level of D-lactic acid, and lower the mortality in 28 days in patients whose APACHE II score was between 8-20. Animal experimental studies showed that in LPS-induced endotoxemia, Tongfu granules were found to protect the intestinal immune function due to reducing the injury of small intestinal mucosa and immune cells and decreasing intestinal lymphocyte apoptosis. In addition, Tongfu granules could protect the intestinal microflora barrier function. Magnolol (5,5-diallyl-2,2-dihydroxybiphenyl) is one of the major active compounds of Tongfu granules. Magnolol treatment was found to prevent by regulating SCF/c-kit and NO signaling to maintain functional interstitial cells of Cajal (ICCs).

Key words: Tongfu granule, magnolol, sepsis, intestinal dysmotility, Cajal cells, immunity

CLC Number:

R285

Su Yanli, Wang Hong, Zhang Shuwen, Wang Baoen, Ren Aimin, Miao Bin, Wang Chao. Exploring therapeutic mechanisms of traditional Chinese medicine Tongfu granule in preventing sepsis-induced intestinal dysmotility[J]. Journal of Capital Medical University, 2015, 36(3): 497-500.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.03.032

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I3/497

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