Abstract: Objective To observe the changes of visual acuity, optical coherence tomography (OCT) and multifocal electroretinogram (mfERG) before and after vitrectomy in patients with idiopathic macular hole (IMH), and explore the sensitive indexes of structural and functional changes in these patients. Methods Data of 34 eyes of 34 patients who underwent vitrectomy from December 2013 to April 2014 in Beijing Tongren Hospital for idiopathic macular hole for IMH were collected. All patients were followed up for 6 months. Best corrected visual acuity(BCVA), mfERG and OCT were examined at baseline, 3 months and 6 months, respectively. The results were analyzed statistically compared with the other eye of patients.Results The patients with idiopathic macular hole suffered a significant reduction in BCVA, as well as mfERG P wave and N₁ amplitude in foveal and perifoveal area (P<0.05). Though the mfERG parameters gradually recovered after operation, can not reach healthy level. This study also observed that the mfERG P wave latency delayed at 3 months postoperatively and recovered at 6 months after surgery. Preoperative BCVA and dmin, dmax were significantly related (ρ=0.549, ρ=0.610, P<0.01),but had no correlation with the parameters of mfERG; postoperative BCVA and central retinal thickness(CRT) were related (P<0.05), and no relationship was found between postoperative BCVA and mfERG parameters.Conclusion The postoperative visual acuity and visual function of eyes with idiopathic macular hole improved. The macular structure and function had a certain degree of recovery. Preoperative and postoperative OCT of main indexes in patients with best corrected vision, preoperative dmin, dmax of patients visual acuity after predictive significance. This study did not find preoperative mfERG parameters on postoperative best corrected visual acuity has prognostic significance.

Key words: idiopathic macular hole, vitrectomy, multifocal electroretinogram(mfERG), optical coherence tomography(OCT)